<html><head><meta http-equiv="Content-Type" content="text/html charset=windows-1252"></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space; "><div>Dear all,</div>We are pleased to announce that the initial annotation of the new human assembly, GRCh38, is now live on Ensembl Pre! <a href="http://pre.ensembl.org/Homo_sapiens/Info/Index/">http://pre.ensembl.org/Homo_sapiens/Info/Index/</a><br><br><br><b>Highlights of GRCh38 Pre! include:</b><div><ul><li>Preliminary gene set including annotation on alternative loci (e.g. MHC haplotypes, LRC region)</li><li>Centromeres covering 2% of the genome</li><li>GENCODE 19 models mapped from e!75 (i.e. from GRCh37)</li><li>CCDS models mapped from e!75</li><li>RefSeq annotation release 106 models</li><li>Human-specific cDNA and EST alignments</li><li>Computed consequences of variants overlapping an Ensembl transcript using the projected Ensembl gene set (Download GVF and VCF files from <a href="ftp://ftp.ensembl.org/pub/pre">Pre! FTP site</a>)</li><li>Computed consequences for variants overlapping NCBI’s RefSeq transcripts (Download GVF and VCF files from <a href="ftp://ftp.ensembl.org/pub/pre">Pre! FTP site</a>)</li><li>Pre! site has been updated to use Solr search</li></ul></div><div><div><br></div><div>In addition to human we're pleased to announce that we also have Pre! sites available for <a href="http://pre.ensembl.org/Poecilia_formosa/Info/Index/">a<a href="http://pre.ensembl.org/Poecilia_formosa/Info/Index/">mazon molly</a></a>, <a href="http://pre.ensembl.org/Macaca_fascicularis/Info/Index/">crab-eating macaque</a> and <a href="http://pre.ensembl.org/Erinaceus_europaeus/Info/Index/">hedgehog</a>.</div><div><br></div><div>Keep an eye out for further GRCh38 annotation updates by checking the blog category <a href="http://www.ensembl.info/blog/category/genebuild/grch38/">GRCh38</a>. </div><div><br></div><div>The Ensembl Pre! blog post with details about the GRCh38 annotation can be viewed here: <a href="http://www.ensembl.info/blog/2014/04/07/pre-site-for-the-new-human-assembly-grch38-is-live/">http://www.ensembl.info/blog/2014/04/07/pre-site-for-the-new-human-assembly-grch38-is-live/</a></div><div><br></div><div>We'll be running a free 20 minute webinar about the data on Ensembl Pre! on Wed 16 April at 4PM BST. To register, click on the following link: <a href="https://attendee.gototraining.com/r/8084872084204567809">https://attendee.gototraining.com/r/8084872084204567809</a></div><div><br>Regards,<div>Rhoda</div><div><br></div><div><br><div>
<div style="color: rgb(0, 0, 0); font-family: Helvetica; font-size: medium; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space; "><div>Rhoda Kinsella Ph.D.</div><div>Ensembl Production Project Leader</div><div>European Bioinformatics Institute (EMBL-EBI)</div><div>European Molecular Biology Laboratory</div><div>Wellcome Trust Genome Campus</div><div>Hinxton,</div><div>Cambridge</div><div>CB10 1SD</div><div><br></div></div><br class="Apple-interchange-newline"><br class="Apple-interchange-newline">
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