<html><head></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space; "><b class=""><i class="">Browsing, searching, analyzing and visualizing pathway data are easier with the new and updated Reactome.<br class=""><span class="Apple-style-span" style="font-style: normal; font-weight: normal; "><br class=""></span></i></b><div class=""><b class=""><i class=""><span class="Apple-style-span" style="font-style: normal; font-weight: normal; ">Reactome has released a new web interface for its open-source curated database of pathways and reactions.</span><br class=""></i></b><div class=""><br class=""></div><div class="">New features include:<br class=""><br class=""></div></div><blockquote class="webkit-indent-blockquote" style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 40px; border-top-style: none; border-right-style: none; border-bottom-style: none; border-left-style: none; border-width: initial; border-color: initial; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; "></blockquote><ul class="MailOutline"><li>A newly designed website with an intuitive user interface for exploring pathway knowledge and a new suite of data analysis tools</li></ul><br class=""><blockquote class="webkit-indent-blockquote" style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 40px; border-top-style: none; border-right-style: none; border-bottom-style: none; border-left-style: none; border-width: initial; border-color: initial; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; "></blockquote><ul class="MailOutline"><li>Pathway Browser, an SBGN-based visualization system of pathway diagrams with advanced navigation features, including zooming, scrolling and event highlighting.</li></ul><br class=""><blockquote class="webkit-indent-blockquote" style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 40px; border-top-style: none; border-right-style: none; border-bottom-style: none; border-left-style: none; border-width: initial; border-color: initial; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; "></blockquote><ul class="MailOutline"><li>PSIQUIC web services to overlay our curated pathway diagrams with molecular interaction data from the Reactome Functional Interaction Network and external interaction databases such as IntAct, BioGRID, ChEMBL, iRefIndex, MINT, and STRING.</li></ul><br class=""><blockquote class="webkit-indent-blockquote" style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 40px; border-top-style: none; border-right-style: none; border-bottom-style: none; border-left-style: none; border-width: initial; border-color: initial; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; "></blockquote><ul class="MailOutline"><li>Pathway and Expression Analysis tools, which allow researchers to analyze experimental datasets by providing ID mapping, pathway assignment and over-representation analysis.</li></ul><br class=""><blockquote class="webkit-indent-blockquote" style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 40px; border-top-style: none; border-right-style: none; border-bottom-style: none; border-left-style: none; border-width: initial; border-color: initial; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; "></blockquote><ul class="MailOutline"><li>Reactome Functional Interaction Network Cytoscape plugin that is useful in the discovery of network patterns related to cancer and other types of disease.</li></ul><br class=""><blockquote class="webkit-indent-blockquote" style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 40px; border-top-style: none; border-right-style: none; border-bottom-style: none; border-left-style: none; border-width: initial; border-color: initial; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; "></blockquote><ul class="MailOutline"><li>Improved tools for display and analysis of Ensembl Compara ortholog-based pathway predictions in 20 non-human species, including the 12 species of the GO Reference Genome Annotation project.</li></ul><blockquote class="webkit-indent-blockquote" style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 40px; border-top-style: none; border-right-style: none; border-bottom-style: none; border-left-style: none; border-width: initial; border-color: initial; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; "></blockquote><br class=""><div class=""><div class=""><ul class="MailOutline"><li>A species Comparison tool, which allow users to compare pathways from another species with human data by providing an overlap indicating the degree of orthology between the two species.</li></ul><div><div class=""><div class=""></div></div></div></div></div><div class=""><div class=""><div class=""><div><br></div><div>A full description of the new features offered by Reactome is available on the new Reactome website at <a href="http://www.reactome.org/">http://www.reactome.org</a>.<br></div><br></div><div class="">Reactome is a collaboration between groups at the Ontario Institute for Cancer Research, Cold Spring Harbor Laboratory, New York University Medical Center, and The European Bioinformatics Institute. Freely available to academic, clinical, and commercial researchers and scientists worldwide, the Reactome database offers pathway data encapsulating areas of human biology ranging from basic pathways of metabolism to complex events such as GPCR signaling and apoptosis, extracted from the published literature by Reactome curatorial staff and cross-referenced to a wide range of standard biological databases. Reactome data and software are distributed under the terms of the Creative Commons Attribution 3.0 Unported License.</div><div class=""><br class=""></div><div class="">For more information contact:<br class="">Robin Haw<br class="">Email: <a href="mailto:help@reactome.org">help@reactome.org</a><br class="">Tel: 647-260-7985</div><div class=""><br></div><div class=""><br></div></div></div><div><span class="Apple-style-span" style="border-collapse: separate; color: rgb(0, 0, 0); font-family: Helvetica; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-border-horizontal-spacing: 0px; -webkit-border-vertical-spacing: 0px; -webkit-text-decorations-in-effect: none; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; font-size: medium; "><div><div><font size="1"><font color="#596D8A"><font><span style="font-size: 9pt; "><b>Robin Haw, PhD<br></b></span></font></font><font><font class="Apple-style-span" size="3"><span class="Apple-style-span" style="font-size: 12px; "><font class="Apple-style-span" size="3"><span class="Apple-style-span" style="font-size: 11px; ">Scientific Associate<br>Manager of Reactome Outreach<br></span></font><br></span></font><font color="#5A6E8B"><b><font class="Apple-style-span" size="3"><span class="Apple-style-span" style="font-size: 12px; ">Ontario Institute for Cancer Research<br></span></font></b></font><font class="Apple-style-span" size="3"><span class="Apple-style-span" style="font-size: 11px; ">MaRS Centre, South Tower<br>101 College Street, Suite 800<br>Toronto, Ontario, Canada M5G 0A3<br> <br>Tel: 647-260-7985<br>Toll-free: 1-866-678-6427<br></span></font><font color="#0000FF"><u><a href="http://www.oicr.on.ca/"><font class="Apple-style-span" size="3"><span class="Apple-style-span" style="font-size: 11px; ">http://www.oicr.on.ca</span></font></a><font class="Apple-style-span" size="3"><span class="Apple-style-span" style="font-size: 11px; "><br></span></font><a href="http://www.reactome.org/"><font class="Apple-style-span" size="3"><span class="Apple-style-span" style="font-size: 11px; ">http://www.reactome.org</span></font></a><font class="Apple-style-span" size="3"><span class="Apple-style-span" style="font-size: 11px; "><br></span></font></u></font></font></font><font><font class="Apple-style-span" size="3"><span class="Apple-style-span" style="font-size: 11px; "><br></span></font></font><font size="1"><font face="Verdana, Helvetica, Arial"><span style="font-size: 8pt; "><font class="Apple-style-span" face="Helvetica">This message and any attachments may contain confidential and/or privileged information for the sole use of the intended recipient. Any review or distribution by anyone other than the person for whom it was originally intended is strictly prohibited. If you have received this message in error, please contact the sender and delete all copies. Opinions, conclusions or other information contained in this message may not be that of the organization.</font></span></font></font></div></div></span></div></body></html>