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<p class=MsoNormal><font size=2 color=navy face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:navy'>Bearing in mind that there are no unmapped
objects Nathan, have you any other ideas what might be happening here?<o:p></o:p></span></font></p>
<p class=MsoNormal><font size=2 color=navy face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:navy'><o:p> </o:p></span></font></p>
<p class=MsoNormal><font size=2 color=navy face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:navy'>Do you think there’s an easy way I could
run exonerate just for these 11 probes to inspect the output?<o:p></o:p></span></font></p>
<p class=MsoNormal><font size=2 color=navy face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:navy'><o:p> </o:p></span></font></p>
<p class=MsoNormal><font size=2 color=navy face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:navy'>Gavin<o:p></o:p></span></font></p>
<p class=MsoNormal><font size=2 color=navy face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:navy'><o:p> </o:p></span></font></p>
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face="Times New Roman"><span style='font-size:12.0pt'>
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<p class=MsoNormal><b><font size=2 face=Tahoma><span style='font-size:10.0pt;
font-family:Tahoma;font-weight:bold'>From:</span></font></b><font size=2
face=Tahoma><span style='font-size:10.0pt;font-family:Tahoma'> Nathan Johnson
[mailto:njohnson@ebi.ac.uk] <br>
<b><span style='font-weight:bold'>Sent:</span></b> 13 January 2011 16:17<br>
<b><span style='font-weight:bold'>To:</span></b> <st1:PersonName w:st="on">Oliver,
Gavin</st1:PersonName><br>
<b><span style='font-weight:bold'>Cc:</span></b> dev@ensembl.org<br>
<b><span style='font-weight:bold'>Subject:</span></b> Re: [ensembl-dev] Funcgen
array mapping - Probeset with strange annotation result</span></font><o:p></o:p></p>
</div>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'><o:p> </o:p></span></font></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'>Hi Gavin<o:p></o:p></span></font></p>
<div>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'><o:p> </o:p></span></font></p>
</div>
<div>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'>Not having mapped this probe set myself, I can't really tell what's
going on. Have you tried looking at the unmapped objects for these
probes? It could be that the other are 'promiscuous'.<o:p></o:p></span></font></p>
</div>
<div>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'><o:p> </o:p></span></font></p>
</div>
<div>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'>Nath<o:p></o:p></span></font></p>
</div>
<div>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'><o:p> </o:p></span></font></p>
</div>
<div>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'><o:p> </o:p></span></font></p>
</div>
<div>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'><o:p> </o:p></span></font></p>
<div>
<div>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'>On 12 Jan 2011, at 11:04, <st1:PersonName w:st="on">Oliver, Gavin</st1:PersonName>
wrote:<o:p></o:p></span></font></p>
</div>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'><br>
<br>
<o:p></o:p></span></font></p>
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<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>Hi all,<u1:p></u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'><u1:p> </u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>One of our users has pointed out a probeset (affy utr
format) that seems to be retrieving some unexpected annotation info via the
FuncGen array mapping environment.<u1:p></u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'><u1:p> </u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>The probeset annotates to<span class=apple-converted-space> </span></span></font><a
name=ENSG00000140853><b><span style='font-weight:bold'>ENSG00000140853</span></b></a><span
class=apple-converted-space><font size=2 face=Arial><span style='font-size:
10.0pt;font-family:Arial'> </span></font></span><font size=2 face=Arial><span
style='font-size:10.0pt;font-family:Arial'> but only seems to return probe
features for four probes i.e. the end result says 4/11 probes align.
However when I look at the alignment manually using Ensembl or NCBI it
looks like all probes align. <u1:p></u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'><u1:p> </u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>To try and ensure that my scripts aren’t doing anything
funny, I set up a quick test like this:<u1:p></u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'><u1:p> </u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>my @probes = @{$probeset->get_all_Probes};<u1:p></u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'><u1:p> </u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'> foreach my $probe
(@probes) {<u1:p></u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>
my @probefeatures = @{$probe->get_all_ProbeFeatures()};<u1:p></u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>
foreach my $feature(@probefeatures) {<u1:p></u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>
print $feature->probe_id."\n";<u1:p></u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>
}<u1:p></u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'> }<u1:p></u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'><u1:p> </u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>And sure enough only 4 probe IDs are returned.<u1:p></u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'><u1:p> </u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>The probes look like this:<u1:p></u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'><u1:p> </u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>>probe:ADXBRCv2a520413:BRRS.12588_at:1019:477;
Interrogation_Position=313; Antisense;<u1:p></u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>CCTGCCCTGGAAGTAATCTTGCTGT<u1:p></u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>>probe:ADXBRCv2a520413:BRRS.12588_at:852:123;
Interrogation_Position=324; Antisense;<u1:p></u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>AGTAATCTTGCTGTCCTGGAATCTC<u1:p></u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>>probe:ADXBRCv2a520413:BRRS.12588_at:665:993;
Interrogation_Position=329; Antisense;<u1:p></u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>TCTTGCTGTCCTGGAATCTCCTCGG<u1:p></u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>>probe:ADXBRCv2a520413:BRRS.12588_at:295:809; Interrogation_Position=353;
Antisense;<u1:p></u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>GGGATGAGGCAGCTGCCGAGCTGGC<u1:p></u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>>probe:ADXBRCv2a520413:BRRS.12588_at:921:949;
Interrogation_Position=383; Antisense;<u1:p></u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>TGCTGCCGAAGATGGGCCGGCTGAA<u1:p></u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>>probe:ADXBRCv2a520413:BRRS.12588_at:1130:813;
Interrogation_Position=478; Antisense;<u1:p></u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>GGGTCTAGCATCCAAGTCATCCGCC<u1:p></u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>>probe:ADXBRCv2a520413:BRRS.12588_at:411:539;
Interrogation_Position=485; Antisense;<u1:p></u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>GCATCCAAGTCATCCGCCTCTGGAA<u1:p></u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>>probe:ADXBRCv2a520413:BRRS.12588_at:94:315;
Interrogation_Position=491; Antisense;<u1:p></u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>AAGTCATCCGCCTCTGGAATAACCC<u1:p></u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>>probe:ADXBRCv2a520413:BRRS.12588_at:307:341;
Interrogation_Position=508; Antisense;<u1:p></u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>AATAACCCCATTCCCTGCGACATGG<u1:p></u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>>probe:ADXBRCv2a520413:BRRS.12588_at:553:511;
Interrogation_Position=524; Antisense;<u1:p></u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>GCGACATGGCCCAGCACCTGAAGAG<u1:p></u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>>probe:ADXBRCv2a520413:BRRS.12588_at:1099:419;
Interrogation_Position=567; Antisense;<u1:p></u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>CTTTGCCTTCTTTGACAACCAGCCC<u1:p></u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'><u1:p> </u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'><u1:p> </u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>Can anyone suggest what might be happening?<u1:p></u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'><u1:p> </u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>Best,<u1:p></u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'><u1:p> </u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>Gavin<u1:p></u1:p></span></font><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'><u1:p> </u1:p><o:p></o:p></span></font></p>
</div>
<div>
<p class=MsoNormal><strong><b><font size=3 color=blue face="Times New Roman"><span
style='font-size:12.0pt;color:blue'> </span></font></b></strong><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><b><font size=3 color=black face="Times New Roman"><span
lang=EN-GB style='font-size:12.0pt;color:black;font-weight:bold'>The contents
of this message and any attachments to it are confidential and may be legally
privileged. If you have received this message in error, you should delete it
from your system immediately and advise the sender.<u1:p></u1:p></span></font><o:p></o:p></b></p>
</div>
<div>
<p class=MsoNormal><b><font size=3 color=black face="Times New Roman"><span
lang=EN-GB style='font-size:12.0pt;color:black;font-weight:bold'><u1:p> </u1:p></span></font><o:p></o:p></b></p>
</div>
<div>
<p class=MsoNormal><b><font size=3 color=black face="Times New Roman"><span
lang=EN-GB style='font-size:12.0pt;color:black;font-weight:bold'>Almac Group
(UK) Limited, registered no. NI061368. <span class=apple-converted-space> </span>Almac
Sciences Limited, registered no. NI041550. <span
class=apple-converted-space> </span>Almac Discovery Limited, registered
no. NI046249.<span class=apple-converted-space> </span> Almac Pharma
Services Limited, registered no. NI045055. <span
class=apple-converted-space> </span>Almac Clinical Services Limited,
registered no. NI041905. <span class=apple-converted-space> </span>Almac
Clinical Technologies Limited, registered no. NI061202.<span
class=apple-converted-space> </span> Almac Diagnostics Limited,
registered no. NI043067. <span class=apple-converted-space> </span>All
preceding companies are registered in<span class=apple-converted-space> <st1:country-region u2:st="on"></span><st1:country-region
w:st="on">Northern Ireland</st1:country-region></st1:country-region><span
class=apple-converted-space> </span>with a registered office address of
Almac House, 20 Seagoe Industrial Estate,<span class=apple-converted-space> <st1:place u2:st="on"><st1:city u2:st="on"></span><st1:place
w:st="on"><st1:City w:st="on">Craigavon</st1:city></st1:City>,<span
class=apple-converted-space> <st1:postalcode u2:st="on"></span><st1:PostalCode
w:st="on">BT63 5QD</st1:postalcode></st1:PostalCode>,<span
class=apple-converted-space> <st1:country-region u2:st="on"></span><st1:country-region
w:st="on">UK</st1:country-region></st1:place></st1:country-region></st1:place>.<span
class=apple-converted-space> </span> <u1:p></u1:p></span></font><o:p></o:p></b></p>
</div>
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<p class=MsoNormal><b><font size=3 color=black face="Times New Roman"><span
lang=EN-GB style='font-size:12.0pt;color:black;font-weight:bold'><u1:p> </u1:p></span></font><o:p></o:p></b></p>
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<p class=MsoNormal><b><font size=3 color=black face="Times New Roman"><span
lang=EN-GB style='font-size:12.0pt;color:black;font-weight:bold'>Almac Sciences
(<st1:country-region u2:st="on"><st1:country-region w:st="on">Scotland</st1:country-region></st1:country-region>)
Limited, registered in<span class=apple-converted-space> <st1:country-region u2:st="on"><st1:place u2:st="on"></span><st1:country-region
w:st="on"><st1:place w:st="on">Scotland</st1:place></st1:country-region></st1:place></st1:country-region><span
class=apple-converted-space> </span>no. SC154034.<u1:p></u1:p></span></font><o:p></o:p></b></p>
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<p class=MsoNormal><b><font size=3 color=black face="Times New Roman"><span
lang=EN-GB style='font-size:12.0pt;color:black;font-weight:bold'><u1:p> </u1:p></span></font><o:p></o:p></b></p>
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<p class=MsoNormal><b><font size=3 color=black face="Times New Roman"><span
lang=EN-GB style='font-size:12.0pt;color:black;font-weight:bold'>Almac Clinical
Services LLC, Almac Clinical Technologies LLC, Almac Diagnostics LLC, Almac
Pharma Services LLC and Almac Sciences LLC are Delaware limited liability
companies and Almac Group Incorporated is a Delaware Corporation. More
information on the Almac Group can be found on the Almac website:<span
class=apple-converted-space> </span><a href="http://www.almacgroup.com">www.almacgroup.com</a><u1:p></u1:p></span></font><o:p></o:p></b></p>
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<p class=MsoNormal><font size=4 face=Helvetica><span style='font-size:13.5pt;
font-family:Helvetica'>_______________________________________________<br>
Dev mailing list<br>
<a href="mailto:Dev@ensembl.org">Dev@ensembl.org</a><br>
<a href="http://lists.ensembl.org/mailman/listinfo/dev">http://lists.ensembl.org/mailman/listinfo/dev</a><o:p></o:p></span></font></p>
</div>
</div>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'></span><o:p> </o:p></span></font></p>
<div><span style='orphans: 2;text-align:auto;widows: 2;-webkit-border-horizontal-spacing: 0px;
-webkit-border-vertical-spacing: 0px;-webkit-text-decorations-in-effect: none;
-webkit-text-size-adjust: auto;-webkit-text-stroke-width: 0;word-spacing:0px'><span
style='-webkit-border-horizontal-spacing: 0px;-webkit-border-vertical-spacing: 0px;
-webkit-text-decorations-in-effect: none;-webkit-text-size-adjust: auto;
orphans: 2;widows: 2;word-spacing:0px'>
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<p class=MsoNormal><font size=1 color=black face=Helvetica><span
style='font-size:9.0pt;font-family:Helvetica;color:black'><span
style='-webkit-border-horizontal-spacing: 0px;-webkit-border-vertical-spacing: 0px;
-webkit-text-decorations-in-effect: none;-webkit-text-size-adjust: auto;
orphans: 2;widows: 2;word-spacing:0px'><span style='-webkit-border-horizontal-spacing: 0px;
-webkit-border-vertical-spacing: 0px;-webkit-text-decorations-in-effect: none;
-webkit-text-size-adjust: auto;orphans: 2;widows: 2;word-spacing:0px'>Nathan
Johnson<o:p></o:p></span></font></p>
</div>
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<p class=MsoNormal><font size=1 color=black face=Helvetica><span
style='font-size:9.0pt;font-family:Helvetica;color:black'>Scientific Programmer<o:p></o:p></span></font></p>
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<p class=MsoNormal><font size=1 color=black face=Helvetica><span
style='font-size:9.0pt;font-family:Helvetica;color:black'>European
Bioinformatics Institute<o:p></o:p></span></font></p>
</div>
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<p class=MsoNormal><font size=1 color=black face=Helvetica><span
style='font-size:9.0pt;font-family:Helvetica;color:black'>Wellcome Trust Genome
Campus<o:p></o:p></span></font></p>
</div>
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<p class=MsoNormal><font size=1 color=black face=Helvetica><span
style='font-size:9.0pt;font-family:Helvetica;color:black'>Hinxton<o:p></o:p></span></font></p>
</div>
<div>
<p class=MsoNormal><st1:City w:st="on"><st1:place w:st="on"><font size=1
color=black face=Helvetica><span style='font-size:9.0pt;font-family:Helvetica;
color:black'>Cambridge</span></font></st1:place></st1:City><font size=1
color=black face=Helvetica><span style='font-size:9.0pt;font-family:Helvetica;
color:black'> CB10 1SD<o:p></o:p></span></font></p>
</div>
<div>
<p class=MsoNormal><font size=1 color=black face=Helvetica><span
style='font-size:9.0pt;font-family:Helvetica;color:black'>Email: <a
href="mailto:njohnson@ebi.ac.uk">njohnson@ebi.ac.uk</a><o:p></o:p></span></font></p>
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<p class=MsoNormal><font size=1 color=black face=Helvetica><span
style='font-size:9.0pt;font-family:Helvetica;color:black'>TelNo: (+44)1223
492629<o:p></o:p></span></font></p>
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<p class=MsoNormal><font size=1 color=black face=Helvetica><span
style='font-size:9.0pt;font-family:Helvetica;color:black'><o:p> </o:p></span></font></p>
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<p class=MsoNormal><font size=1 color=black face=Helvetica><span
style='font-size:9.0pt;font-family:Helvetica;color:black'><o:p> </o:p></span></font></p>
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<p class=MsoNormal><font size=1 color=black face=Helvetica><span
style='font-size:9.0pt;font-family:Helvetica;color:black'><br>
<br>
</span></font><o:p></o:p></p>
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</span></span></span></span>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'><o:p> </o:p></span></font></p>
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<!--[object_id=#almacgroup.com#]--><FONT face=Tahoma size=2>
<P class=MsoNormal><STRONG><B><SPAN style="FONT-SIZE: 12pt; COLOR: blue"><FONT face="Times New Roman"> </FONT></P>
<P class=MsoNormal><FONT color=#000000><SPAN lang=EN-GB style="FONT-FAMILY: 'Times New Roman'">The contents of this message and any attachments to it are confidential and may be legally privileged. If you have received this message in error, you should delete it from your system immediately and advise the sender.<?xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" /><o:p></o:p></SPAN></FONT></P>
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<P class=MsoNormal style="mso-layout-grid-align: none"><FONT color=#0000ff><SPAN lang=EN-GB style="COLOR: black; FONT-FAMILY: 'Times New Roman'">Almac Group (UK) Limited, registered no. NI061368.<SPAN style="mso-spacerun: yes"> </SPAN>Almac Sciences Limited, registered no. NI041550.<SPAN style="mso-spacerun: yes"> </SPAN>Almac Discovery Limited, registered no. NI046249. <SPAN style="mso-spacerun: yes"> </SPAN>Almac Pharma Services Limited, registered no. NI045055.<SPAN style="mso-spacerun: yes"> </SPAN>Almac Clinical Services Limited, registered no. NI041905.<SPAN style="mso-spacerun: yes"> </SPAN>Almac Clinical Technologies Limited, registered no. NI061202. <SPAN style="mso-spacerun: yes"> </SPAN>Almac Diagnostics Limited, registered no. NI043067.<SPAN style="mso-spacerun: yes"> </SPAN>All preceding companies are registered in <?xml:namespace prefix = st1 ns = "urn:schemas-microsoft-com:office:smarttags" /><st1:country-region w:st="on">Northern Ireland</st1:country-region> with a registered office address of Almac House, 20 Seagoe Industrial Estate, <st1:place w:st="on"><st1:City w:st="on">Craigavon</st1:City>, <st1:PostalCode w:st="on">BT63 5QD</st1:PostalCode>, <st1:country-region w:st="on">UK</st1:country-region></st1:place>. <SPAN style="mso-spacerun: yes"> </SPAN><o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal style="mso-layout-grid-align: none"><SPAN lang=EN-GB style="COLOR: black; FONT-FAMILY: 'Times New Roman'"><o:p> </o:p></SPAN></P>
<P class=MsoNormal style="mso-layout-grid-align: none"><SPAN lang=EN-GB style="COLOR: black; FONT-FAMILY: 'Times New Roman'">Almac Sciences (<st1:country-region w:st="on">Scotland</st1:country-region>) Limited, registered in <st1:country-region w:st="on"><st1:place w:st="on">Scotland</st1:place></st1:country-region> no. SC154034. <o:p></o:p></SPAN></P>
<P class=MsoNormal style="mso-layout-grid-align: none"><SPAN lang=EN-GB style="COLOR: black; FONT-FAMILY: 'Times New Roman'"><o:p> </o:p></SPAN></P>
<P class=MsoNormal style="mso-layout-grid-align: none"><SPAN lang=EN-GB style="COLOR: black; FONT-FAMILY: 'Times New Roman'">Almac Clinical Services LLC, Almac Clinical Technologies LLC, Almac Diagnostics LLC, Almac Pharma Services LLC and Almac Sciences LLC are Delaware limited liability companies and Almac Group Incorporated is a Delaware Corporation. More information on the Almac Group can be found on the Almac website: <A href="http://www.almacgroup.com">www.almacgroup.com</A><o:p></o:p></SPAN></P></SPAN></B></STRONG></FONT></body>
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