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<P class=MsoNormal><FONT color=navy size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; COLOR: navy; FONT-SIZE: 10pt">Nathan – the problem
seems to have been with the probe2transcript UTR parameters.
<o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT color=navy size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; COLOR: navy; FONT-SIZE: 10pt"><o:p> </o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT color=navy size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; COLOR: navy; FONT-SIZE: 10pt">I supplied the
following <o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT color=navy size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; COLOR: navy; FONT-SIZE: 10pt"><o:p> </o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT color=navy size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; COLOR: navy; FONT-SIZE: 10pt">“</SPAN></FONT><FONT
size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">--unannotated_5_utr 0
--unannotated_3_utr 0 -annotated_5_prime_extend 0 -annotated_3_prime_extend
0”</SPAN></FONT><o:p></o:p></P>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt"><o:p> </o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT color=navy size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; COLOR: navy; FONT-SIZE: 10pt">Which are the precise
same parameters I supplied on the last run (v60) which worked
perfectly.<o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT color=navy size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; COLOR: navy; FONT-SIZE: 10pt"><o:p> </o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT color=navy size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; COLOR: navy; FONT-SIZE: 10pt">Now they don’t
work.<o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT color=navy size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; COLOR: navy; FONT-SIZE: 10pt"><o:p> </o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT color=navy size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; COLOR: navy; FONT-SIZE: 10pt">Using “--calculate_utrs
--utr_multiplier 1” works fine but I don’t want to extend
UTRs.<o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT color=navy size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; COLOR: navy; FONT-SIZE: 10pt"><o:p> </o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT color=navy size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; COLOR: navy; FONT-SIZE: 10pt">Has something changed
between versions 60 and 61 that would alter the behavior of these
variables?<o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT color=navy size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; COLOR: navy; FONT-SIZE: 10pt"><o:p> </o:p></SPAN></FONT></P></FONT></DIV><BR>
<DIV dir=ltr lang=en-us class=OutlookMessageHeader align=left><FONT size=1
face="Times New Roman"><SPAN
style="FONT-SIZE: 8pt"><U1:P> </U1:P></SPAN></FONT><o:p></o:p></DIV>
<DIV class=Section1>
<DIV>
<DIV>
<DIV
style="WORD-WRAP: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space"
vlink="blue" link="blue">
<DIV>
<DIV>
<DIV>
<P class=MsoNormal><FONT size=1 face="Times New Roman"><SPAN
style="FONT-SIZE: 8pt"><U1:P> </U1:P></SPAN></FONT><o:p></o:p></P></DIV></DIV>
<DIV>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt"><U1:P> </U1:P><o:p></o:p></SPAN></FONT></P>
<DIV>
<DIV>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt">On 2 Mar 2011, at 12:31, Oliver, Gavin
wrote:<U1:P></U1:P><o:p></o:p></SPAN></FONT></P></DIV>
<P style="MARGIN-BOTTOM: 12pt" class=MsoNormal><FONT size=3
face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt"><U1:P> </U1:P><o:p></o:p></SPAN></FONT></P><SPAN
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<DIV>
<P style="LINE-HEIGHT: 16.3pt" class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Hi,<U3:P></U3:P></SPAN></FONT><U1:P></U1:P><o:p></o:p></P></DIV>
<DIV>
<P style="LINE-HEIGHT: 16.3pt" class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><U3:P> </U3:P></SPAN></FONT><U1:P></U1:P><o:p></o:p></P></DIV>
<DIV>
<P style="LINE-HEIGHT: 16.3pt" class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">I have rerun my array annotations
with v61. Everything seemed fine until I looked at the log and saw that
perhaps 2 probesets per array have actually mapped to a
transcript.<U3:P></U3:P></SPAN></FONT><U1:P></U1:P><o:p></o:p></P></DIV>
<DIV>
<P style="LINE-HEIGHT: 16.3pt" class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Can you think of something obvious
that might have gone wrong here? The log output is
below.<U3:P></U3:P></SPAN></FONT><U1:P></U1:P><o:p></o:p></P></DIV>
<DIV>
<P style="LINE-HEIGHT: 16.3pt" class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><U3:P> </U3:P></SPAN></FONT><U1:P></U1:P><o:p></o:p></P></DIV>
<DIV>
<P style="LINE-HEIGHT: 16.3pt" class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Best,<U3:P></U3:P></SPAN></FONT><U1:P></U1:P><o:p></o:p></P></DIV>
<DIV>
<P style="LINE-HEIGHT: 16.3pt" class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><U3:P> </U3:P></SPAN></FONT><U1:P></U1:P><o:p></o:p></P></DIV>
<DIV>
<P style="LINE-HEIGHT: 16.3pt" class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Gavin<U3:P></U3:P></SPAN></FONT><U1:P></U1:P><o:p></o:p></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><U3:P> </U3:P></SPAN></FONT><U1:P></U1:P><o:p></o:p></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><U3:P> </U3:P></SPAN></FONT><U1:P></U1:P><o:p></o:p></P></DIV>
<DIV>
<P style="LINE-HEIGHT: 16.3pt" class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">(Nathan I’m posting here incase you
didn’t receive my
mail)</SPAN></FONT><U1:P></U1:P><o:p></o:p></P></DIV><U3:P></U3:P>
<DIV>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt"><U3:P> </U3:P><U1:P></U1:P><o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt"><U3:P> </U3:P><U1:P></U1:P><o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt">::
:: Running on<SPAN
class=apple-converted-space> </SPAN><A
href="http://probe2transcript.pl/">probe2transcript.pl</A><SPAN
class=apple-converted-space> </SPAN>on:<SPAN
class=apple-converted-space> </SPAN><A
href="http://ni-cr-svc-slv.phar-services.com/">ni-cr-svc-slv.phar-services.com</A>
:: :: - Mon Feb 21 09:01:02
2011<U3:P></U3:P><U1:P></U1:P><o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt"><U3:P> </U3:P><U1:P></U1:P><o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt">:: Params
are: --species homo_sapiens --transcript_dbname
homo_sapiens_core_61_37f --transcript_host ni-cr-svc-bs3 --transcript_port 3306
--transcript_user root --transcript_pass pass --xref_host ni-cr-svc-bs3
--xref_dbname homo_sapiens_funcgen_61_37f --xref_user root --xref_pass pass
--unannotated_5_utr 0 --unannotated_3_utr 0 -annotated_5_prime_extend 0
-annotated_3_prime_extend 0 --threshold 0.000005 --mismatches 2 -vendor AFFY
-format AFFY_UTR -arrays ADXOCv1a520630 ADXBRCv2a520413 ADXECv1a520743
ADXLCv1a520538 ADXCRCG2a520319 HG-U133_Plus_2 ADXPCv1a520642
-import_edb<U3:P></U3:P><U1:P></U1:P><o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt">:: No probe DB params
specified, defaulting to xref
params<U3:P></U3:P><U1:P></U1:P><o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt"><U3:P> </U3:P><U1:P></U1:P><o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt"><U3:P> </U3:P><U1:P></U1:P><o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt">::
:: Checking existing Xrefs
::
::<U3:P></U3:P><U1:P></U1:P><o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt"><U3:P> </U3:P><U1:P></U1:P><o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt">:: You have specified
-utr_multiplier and a -3|5_prime_extend, -3|5_prime_extend will override where
appropriate<U3:P></U3:P><U1:P></U1:P><o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt">:: Setting 3 unannotated
UTR length to 0<U3:P></U3:P><U1:P></U1:P><o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt">:: Setting 5 unannotated
UTR length to 0<U3:P></U3:P><U1:P></U1:P><o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt">:: Identified 167074
transcripts for probe
mapping<U3:P></U3:P><U1:P></U1:P><o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt">:: Allowed mismatches =
2<U3:P></U3:P><U1:P></U1:P><o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt">:: Caching arrays per
ProbeSet - Mon Feb 21 09:01:21
2011<U3:P></U3:P><U1:P></U1:P><o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt">:: Performing overlap
analysis. %
Complete:<U3:P></U3:P><U1:P></U1:P><o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt">:: 0 ::
1 :: 2 :: 3 :: 4
:: 5 :: 6 :: 7
:: 8 :: 9 :: 10
:: 11 :: 12 :: 13 :: 14
:: 15 :: 16 :: 17 :: 18 ::
19 :: 20 :: 21 :: 22 :: 23
:: 24 :: 25 :: 26 :: 27
:: 28 :: 29 :: 30 :: 31
:: 32 :: 33 :: 34 :: 35
:: 36 :: 37 :: 38 :: 39
:: 40 :: 41 :: 42 :: 43
:: 44 :: 45 :: 46 :: 47
:: 48 :: 49 :: 50 :: 51
:: 52 :: 53 :: 54 :: 55
:: 56 :: 57 :: 58 :: 59
:: 60 :: 61 :: 62 :: 63
:: 64 :: 65 :: 66 :: 67
:: 68 :: 69 :: 70 :: 71
:: 72 :: 73 :: 74 :: 75
:: 76 :: 77 :: 78 :: 79
:: 80 :: 81 :: 82 :: 83
:: 84 :: 85 :: 86 :: 87
:: 88 :: 89 :: 90 :: 91
:: 92 :: 93 :: 94 :: 95
:: 96 :: 97 :: 98 :: 99
::<U3:P></U3:P><U1:P></U1:P><o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt">:: Failed to extend 1
transcripts<U3:P></U3:P><U1:P></U1:P><o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt">:: Seen 0 5 prime UTRs
with and average length of
0<U3:P></U3:P><U1:P></U1:P><o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt">:: Seen 0 3 prime UTRs
with and average length of
0<U3:P></U3:P><U1:P></U1:P><o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt"><U3:P> </U3:P><U1:P></U1:P><o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt"><U3:P> </U3:P><U1:P></U1:P><o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt">::
:: Writing ADXOCv1a520630 ADXBRCv2a520413
ADXECv1a520743 ADXLCv1a520538 ADXCRCG2a520319 HG-U133_Plus_2 ADXPCv1a520642
Xrefs ::
:: - Mon Feb 21 18:26:37
2011<U3:P></U3:P><U1:P></U1:P><o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt"><U3:P> </U3:P><U1:P></U1:P><o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt">:: Logging probesets that
don't map to any transcripts - Mon Feb 21 18:26:37
2011<U3:P></U3:P><U1:P></U1:P><o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt">:: Updating 0 promiscuous
probesets - Mon Feb 21 18:40:28
2011<U3:P></U3:P><U1:P></U1:P><o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt">:: UnmappedObjects
loaded:
598994<U3:P></U3:P><U1:P></U1:P><o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt">:: ADXBRCv2a520413
distinct ProbeSet xrefs mapped(total xrefs):
1/60856(1)<U3:P></U3:P><U1:P></U1:P><o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt">:: ADXOCv1a520630 distinct
ProbeSet xrefs mapped(total xrefs):
4/120373(7)<U3:P></U3:P><U1:P></U1:P><o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt">:: ADXECv1a520743 distinct
ProbeSet xrefs mapped(total xrefs):
4/111012(7)<U3:P></U3:P><U1:P></U1:P><o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt">:: ADXLCv1a520538 distinct
ProbeSet xrefs mapped(total xrefs):
4/60416(10)<U3:P></U3:P><U1:P></U1:P><o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt">:: ADXCRCG2a520319
distinct ProbeSet xrefs mapped(total xrefs):
2/61528(2)<U3:P></U3:P><U1:P></U1:P><o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt">:: HG-U133_Plus_2 distinct
ProbeSet xrefs mapped(total xrefs):
1/54675(4)<U3:P></U3:P><U1:P></U1:P><o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt">:: ADXPCv1a520642 distinct
ProbeSet xrefs mapped(total xrefs):
2/121563(2)<U3:P></U3:P><U1:P></U1:P><o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt">:: Mapped 9/167074
transcripts - Mon Feb 21 18:40:39
2011<U3:P></U3:P><U1:P></U1:P><o:p></o:p></SPAN></FONT></P></DIV>
<P class=MsoNormal><FONT size=4 face=Helvetica><SPAN
style="FONT-FAMILY: Helvetica; FONT-SIZE: 13.5pt">_______________________________________________<BR>Dev
mailing list<BR><A href="mailto:Dev@ensembl.org">Dev@ensembl.org</A><BR><A
href="http://lists.ensembl.org/mailman/listinfo/dev">http://lists.ensembl.org/mailman/listinfo/dev</A><U1:P></U1:P></SPAN></FONT><o:p></o:p></P></DIV></DIV></SPAN>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt"><U1:P> </U1:P><o:p></o:p></SPAN></FONT></P>
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<P class=MsoNormal><B><FONT color=black size=3 face="Times New Roman"><SPAN
style="COLOR: black; FONT-SIZE: 12pt; FONT-WEIGHT: bold" lang=EN-GB>The contents
of this message and any attachments to it are confidential and may be legally
privileged. If you have received this message in error, you should delete it
from your system immediately and advise the
sender.<U1:P></U1:P></SPAN></FONT><o:p></o:p></B></P>
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style="COLOR: black; FONT-SIZE: 12pt; FONT-WEIGHT: bold"
lang=EN-GB><U1:P> </U1:P></SPAN></FONT><o:p></o:p></B></P>
<P class=MsoNormal><B><FONT color=black size=3 face="Times New Roman"><SPAN
style="COLOR: black; FONT-SIZE: 12pt; FONT-WEIGHT: bold" lang=EN-GB>Almac Group
(UK) Limited, registered no. NI061368. Almac Sciences Limited, registered
no. NI041550. Almac Discovery Limited, registered no. NI046249.
Almac Pharma Services Limited, registered no. NI045055. Almac Clinical
Services Limited, registered no. NI041905. Almac Clinical Technologies
Limited, registered no. NI061202. Almac Diagnostics Limited, registered
no. NI043067. All preceding companies are registered in
<st1:country-region u2:st="on"><st1:country-region w:st="on">Northern
Ireland</st1:country-region></st1:country-region> with a registered office
address of Almac House, 20 Seagoe Industrial Estate, <st1:place
u2:st="on"><st1:city u2:st="on"><st1:place w:st="on"><st1:City
w:st="on">Craigavon</st1:City></st1:city>, <st1:postalcode
u2:st="on"><st1:PostalCode w:st="on">BT63 5QD</st1:PostalCode></st1:postalcode>,
<st1:country-region u2:st="on"><st1:country-region
w:st="on">UK</st1:country-region></st1:place></st1:country-region></st1:place>.
<U1:P></U1:P></SPAN></FONT><o:p></o:p></B></P>
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style="COLOR: black; FONT-SIZE: 12pt; FONT-WEIGHT: bold"
lang=EN-GB><U1:P> </U1:P></SPAN></FONT><o:p></o:p></B></P>
<P class=MsoNormal><B><FONT color=black size=3 face="Times New Roman"><SPAN
style="COLOR: black; FONT-SIZE: 12pt; FONT-WEIGHT: bold" lang=EN-GB>Almac
Sciences (<st1:country-region u2:st="on"><st1:country-region
w:st="on">Scotland</st1:country-region></st1:country-region>) Limited,
registered in <st1:country-region u2:st="on"><st1:place
u2:st="on"><st1:country-region w:st="on"><st1:place
w:st="on">Scotland</st1:place></st1:country-region></st1:place></st1:country-region>
no. SC154034. <U1:P></U1:P></SPAN></FONT><o:p></o:p></B></P>
<P class=MsoNormal><B><FONT color=black size=3 face="Times New Roman"><SPAN
style="COLOR: black; FONT-SIZE: 12pt; FONT-WEIGHT: bold"
lang=EN-GB><U1:P> </U1:P></SPAN></FONT><o:p></o:p></B></P>
<P class=MsoNormal><B><FONT color=black size=3 face="Times New Roman"><SPAN
style="COLOR: black; FONT-SIZE: 12pt; FONT-WEIGHT: bold" lang=EN-GB>Almac
Clinical Services LLC, Almac Clinical Technologies LLC, Almac Diagnostics LLC,
Almac Pharma Services LLC and Almac Sciences LLC are Delaware limited liability
companies and Almac Group Incorporated is a Delaware Corporation. More
information on the Almac Group can be found on the Almac website: <A
href="http://www.almacgroup.com/">www.almacgroup.com</A><U1:P></U1:P></SPAN></FONT><o:p></o:p></B></P></DIV></DIV>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt"><o:p> </o:p></SPAN></FONT></P></U1:SMARTTAGTYPE></U1:SMARTTAGTYPE>
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<DIV>
<P class=MsoNormal><FONT color=black size=1 face=Helvetica><SPAN
style="FONT-FAMILY: Helvetica; COLOR: black; FONT-SIZE: 8pt"><SPAN
style="WIDOWS: 2; ORPHANS: 2; WORD-SPACING: 0px; -webkit-border-horizontal-spacing: 0px; -webkit-border-vertical-spacing: 0px; -webkit-text-decorations-in-effect: none; -webkit-text-size-adjust: auto"><SPAN
style="WIDOWS: 2; ORPHANS: 2; WORD-SPACING: 0px; -webkit-border-horizontal-spacing: 0px; -webkit-border-vertical-spacing: 0px; -webkit-text-decorations-in-effect: none; -webkit-text-size-adjust: auto">Nathan
Johnson<o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT color=black size=1 face=Helvetica><SPAN
style="FONT-FAMILY: Helvetica; COLOR: black; FONT-SIZE: 8pt">Scientific
Programmer<o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT color=black size=1 face=Helvetica><SPAN
style="FONT-FAMILY: Helvetica; COLOR: black; FONT-SIZE: 8pt">European
Bioinformatics Institute<o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT color=black size=1 face=Helvetica><SPAN
style="FONT-FAMILY: Helvetica; COLOR: black; FONT-SIZE: 8pt">Wellcome Trust
Genome Campus<o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT color=black size=1 face=Helvetica><SPAN
style="FONT-FAMILY: Helvetica; COLOR: black; FONT-SIZE: 8pt">Hinxton<o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><st1:City w:st="on"><st1:place w:st="on"><FONT color=black
size=1 face=Helvetica><SPAN
style="FONT-FAMILY: Helvetica; COLOR: black; FONT-SIZE: 8pt">Cambridge</SPAN></FONT></st1:place></st1:City><FONT
color=black size=1 face=Helvetica><SPAN
style="FONT-FAMILY: Helvetica; COLOR: black; FONT-SIZE: 8pt"> CB10
1SD<o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT color=black size=1 face=Helvetica><SPAN
style="FONT-FAMILY: Helvetica; COLOR: black; FONT-SIZE: 8pt">Email: <A
href="mailto:njohnson@ebi.ac.uk">njohnson@ebi.ac.uk</A><o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT color=black size=1 face=Helvetica><SPAN
style="FONT-FAMILY: Helvetica; COLOR: black; FONT-SIZE: 8pt">TelNo: (+44)1223
492629<o:p></o:p></SPAN></FONT></P></DIV>
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