<html><head></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space; ">Hello Zhaojun,<div><br></div><div>The region you are looking at is highly repetitive which makes variant calling difficult and which could be the reason</div><div>for many co-located variants. To answer your second question: There are no variants reported for the strains in the selected region. </div><div><br></div><div>Hope this helps.</div><div><br></div><div>Kind regards,</div><div>Anja</div><div><div><br><div><div>On 22 Apr 2013, at 20:17, Zhaojun Zhang wrote:</div><br class="Apple-interchange-newline"><blockquote type="cite"><div dir="ltr"><br><div class="gmail_quote"><br><div dir="ltr"><div>Hi,</div><div><br></div><div>I am working on the GVF database of Ensembl, recently. I downloaded the newest version of GVF file from the website. </div><div>
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And I found out there is chromosome 14:19415857-19418930 is a very dense SNV region, and also several SNVs are located at the exact same location. Is it normal?</div><div><br></div><div>You could use "head -n 28042193 Mus_musculus.gvf | tail -n 100" to check out the region.</div>
<div><br></div><div>However, I could not see any variants in resequencing query:</div><div><br></div><a href="http://useast.ensembl.org/Mus_musculus/Location/SequenceAlignment?db=core;g=ENSMUSG00000095280;r=14:19415857-19418930;t=ENSMUST00000177817" target="_blank">http://useast.ensembl.org/Mus_musculus/Location/SequenceAlignment?db=core;g=ENSMUSG00000095280;r=14:19415857-19418930;t=ENSMUST00000177817</a><br>
<div><br></div><div>Best,</div><div>Zhaojun.</div></div>
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