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<div class="moz-cite-prefix">Hello Chris,<br>
<br>
As I said I'm implementing this as an Ensembl Variant Effect
Predictor plugin.<br>
Input is an VCF file.<br>
<br>
Best regards,<br>
Guillermo.<br>
<br>
On 04/29/13 10:03, <a class="moz-txt-link-abbreviated" href="mailto:cj5@sanger.ac.uk">cj5@sanger.ac.uk</a> wrote:<br>
</div>
<blockquote
cite="mid:060c19fc5f32bcf1ffafb10a1477a26e.squirrel@webmail.sanger.ac.uk"
type="cite">
<pre wrap="">Hi Guillermo,
Not sure of your requrements, but if you want a simple lookup of a mtrix based upon the original paper,
Grantham, R. Amino Acid Difference Formula to Help Explain Protein Evolution, Science 1974 Sep 6;185(4154):862-4.
please see attached.
regards
Chris Joyce
</pre>
<blockquote type="cite">
<pre wrap="">Hello,
I'm trying to calculate Grantham AA distance as a VEP plugin.
Currently I'm doing it parsing HGSVp and calculating distance between
the two AA being parsed.
Do you guys believe there's an easier and more efficient way to do this?
Thank you.
Best regards,
Guillermo.
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