<html><head></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space; ">Dear Duarte,<div><br></div><div>The reason for the discrepancy is that in Ensembl we report the alleles always in the forward strand, where in dbSNP they report them as they were submitted by the submitters.</div><div><br></div><div>In this case the have been reported in reverse orientation.</div><div><br></div><div><img height="139" width="959" apple-width="yes" apple-height="yes" id="b94db987-1f5f-46bc-a7fb-7963331cec35" src="cid:0B27B41F-3C13-40CF-A3FE-8B47FE84D50B@windows.ebi.ac.uk"></div><div><br></div><div>Regards,</div><div>Denise</div><div><br></div><div><br><div><div>On 23 May 2013, at 17:25, Duarte Molha wrote:</div><br class="Apple-interchange-newline"><blockquote type="cite"><div dir="ltr"><div>Dear developers</div><div><br></div><div>I was wondering if someone could explain to me the difference I see in this <span class="" style="">RSid</span></div><div><b style="font-size:13px;font-family:arial,helvetica,sans-serif">rs4970378    </b><br>


</div><div><font color="#000000" face="arial, helvetica, sans-serif">in the <span class="" style="">Ensembl</span> database and in the <span class="" style="">NCBI</span> <span class="" style="">snp</span> database</font></div><div>

<font color="#000000" face="arial, helvetica, sans-serif"><br></font></div>
<div><font color="#000000" face="arial, helvetica, sans-serif"><br></font></div><div><a href="http://www.ensembl.org/Homo_sapiens/Variation/Context?r=1:883125-884125;source=dbSNP;v=rs4970378;vdb=variation;vf=3859232" target="_blank">http://www.<span class="" style="">ensembl</span>.org/Homo_<span class="" style="">sapiens</span>/Variation/Context?r=1:883125-884125;source=<span class="" style="">dbSNP</span>;v=rs4970378;<span class="" style="">vdb</span>=variation;<span class="" style="">vf</span>=3859232</a><br>


</div><div><br></div><div><a href="http://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=4970378" target="_blank">http://www.<span class="" style="">ncbi</span>.<span class="" style="">nlm</span>.<span class="" style="">nih</span>.gov/projects/<span class="" style="">SNP</span>/<span class="" style="">snp</span>_ref.<span class="" style="">cgi</span>?rs=4970378</a><br>

</div><div><br></div><div>in <span class="" style="">NCBI</span> the alleles are <span style="font-size:13px;background-color:rgb(241,241,241);font-family:arial,helvetica,sans-serif">C/T</span></div>
<div><span class="" style="">ln</span> <span class="" style="">Ensembl</span> they are AG<br></div><div><br></div><div style="">Why the discrepancy?</div><div style=""><br></div>thanks<div><br></div><div><span class="" style="">Duarte</span></div>

<div><br clear="all"><div><font style="" color="#999999">=========================<br>     <span class="" style="">Duarte</span> Miguel Paulo <span class="" style="">Molha</span>      <br>
</font><div><font style="" color="#999999">         <a href="http://about.me/duarte" target="_blank">http://about.me/<span class="" style="">duarte</span></a>         <br>=========================</font></div></div>
</div></div>
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