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Hi Paolo,<br>
<br>
The variation provides a vep cache for all species with variation
data<br>
<a class="moz-txt-link-freetext"
href="ftp://ftp.ensembl.org/pub/release-75/variation/VEP/">ftp://ftp.ensembl.org/pub/release-75/variation/VEP/</a><br>
<br>
This cache contains all known variations, ordered by location.<br>
Combined with a fasta file for the genomic sequence, this means we
can access all the required information from file rather than
querying the database every time.<br>
<br>
With single queries, the performance is comparable.<br>
If you are running multiple queries, especially if you are working
on the same region, the file retrieval is faster as it can re-use
indexed data.<br>
<br>
<br>
Regards,<br>
Magali<br>
<br>
<div class="moz-cite-prefix">On 23/07/2014 10:14, Paolo Cozzi wrote:<br>
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<blockquote cite="mid:53CF7D0B.1030408@itb.cnr.it" type="cite">
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Dear Magali,<br>
<br>
Thank you for your replay and your support. Could you describe
briefly vep cache? is something like memcached?<br>
<br>
At the moment, I don't think that I need faster performance on
other species, but I will remember your suggestion.<br>
<br>
Regards,<br>
<br>
Paolo.<br>
<br>
<br>
<br>
Il 22/07/2014 18:36, mag ha scritto:<br>
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Hi Paolo,<br>
<br>
Thank you for reporting this and apologies for the error.<br>
<br>
We were wrongly using some human-specific configuration for all
species, this has now been fixed on the live server.<br>
<br>
If you are using POST requests for VEP, please be aware that
only human uses the vep cache.<br>
For other species, we are still using direct database
connection, which will result in lower performance.<br>
<br>
If you are interested in getting faster POST support for other
species, please contact us.<br>
<br>
<br>
Regards,<br>
Magali<br>
<br>
<div class="moz-cite-prefix">On 22/07/2014 11:55, Paolo Cozzi
wrote:<br>
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<blockquote cite="mid:53CE4329.7000107@itb.cnr.it" type="cite">
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<br>
Dear developer,<br>
<br>
I found an odd response from the
<meta http-equiv="content-type" content="text/html;
charset=ISO-8859-1">
<a moz-do-not-send="true"
href="http://rest.ensembl.org/documentation/info/vep_region_post"
style="color: rgb(0, 85, 128); text-decoration: underline;
outline: 0px; font-family: 'Helvetica Neue', Helvetica,
Arial, sans-serif; font-size: 14px; font-style: normal;
font-variant: normal; font-weight: normal; letter-spacing:
normal; line-height: 20px; orphans: auto; text-align: left;
text-indent: 0px; text-transform: none; white-space: normal;
widows: auto; word-spacing: 0px; -webkit-text-stroke-width:
0px;">vep/:species/region/</a> of the new ensembl REST
server (
<meta http-equiv="content-type" content="text/html;
charset=ISO-8859-1">
<a moz-do-not-send="true" href="http://rest.ensembl.org/">http://rest.ensembl.org/</a>)
while searching for species other than human. For example, if
I do 2 POST request with curl on human and cow (the sample
data are the same as in the VEP webserver):<br>
<br>
$ curl -H "content-type:application/json" -H
"accept:application/json" --data '{ "variants" : ["1 909238
909238 G/C +", "3 361464 361464 A/- +", "5 121187650
121188519 DUP"] }' <a moz-do-not-send="true"
class="moz-txt-link-freetext"
href="http://rest.ensembl.org/vep/human/region">http://rest.ensembl.org/vep/human/region</a>
> output_human.txt<br>
<br>
$ curl -H "content-type:application/json" -H
"accept:application/json" --data '{ "variants" : ["1 909238
909238 G/C +", "3 361464 361464 A/- +", "5 121187650
121188519 DUP"] }' <a moz-do-not-send="true"
class="moz-txt-link-freetext"
href="http://rest.ensembl.org/vep/cow/region">http://rest.ensembl.org/vep/cow/region</a>
> output_cow.txt <br>
<br>
I will find the same results (diff give me no output), even
VEP gives me 2 different results. Could be a problem of
variation endpoint?<br>
<br>
Thanks for your support,<br>
<br>
best regards,<br>
<br>
Paolo.<br>
<br>
<br>
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