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</o:shapelayout></xml><![endif]--></head><body lang=EN-GB link="#0563C1" vlink="#954F72"><div class=WordSection1><p class=MsoNormal>Dear Developers<o:p></o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal>I am using the perl API to fetch details about a list of genes and am trying to understand why a gene symbol is failing to query against GRCH37.<o:p></o:p></p><h1 style='mso-margin-top-alt:0cm;margin-right:0cm;margin-bottom:12.0pt;margin-left:0cm;background:white'><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;font-weight:normal'>The gene SUGCT (ENSG00000175600) is on the database:<o:p></o:p></span></h1><h1 style='mso-margin-top-alt:0cm;margin-right:0cm;margin-bottom:12.0pt;margin-left:0cm;background:white'><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;font-weight:normal'><a href="http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000175600;r=7:40174575-40900362">http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000175600;r=7:40174575-40900362</a><o:p></o:p></span></h1><h1 style='mso-margin-top-alt:0cm;margin-right:0cm;margin-bottom:12.0pt;margin-left:0cm;background:white'><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;font-weight:normal'>The correct HGNC symbol is SUGCT, however, when querying for it<o:p></o:p></span></h1><h1 style='background:white'><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;font-weight:normal'>Using:<o:p></o:p></span></h1><h1 style='background:white'><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;font-weight:normal'> my @fetched_genes = @{$gene_adaptor->fetch_all_by_display_label (“SUGCT”)};<o:p></o:p></span></h1><h1 style='mso-margin-top-alt:0cm;margin-right:0cm;margin-bottom:12.0pt;margin-left:0cm;background:white'><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;font-weight:normal'>or <o:p></o:p></span></h1><h1 style='mso-margin-top-alt:0cm;margin-right:0cm;margin-bottom:12.0pt;margin-left:0cm;background:white'><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;font-weight:normal'>my @fetched_genes = @{ $gene_adaptor->fetch_all_by_external_name(“SUGCT”) };<o:p></o:p></span></h1><h1 style='mso-margin-top-alt:0cm;margin-right:0cm;margin-bottom:12.0pt;margin-left:0cm;background:white'><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;font-weight:normal'>The query fails…This is because the HGNC symbol recorded for this gene on your database is “C7orf10”<o:p></o:p></span></h1><h1 style='mso-margin-top-alt:0cm;margin-right:0cm;margin-bottom:12.0pt;margin-left:0cm;background:white'><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;font-weight:normal'>This is not the current HGNC symbol for the gene and I am struggling to understand why, if your own display lists the correct symbol for the gene, why is the underlying database not updated accordingly.<o:p></o:p></span></h1><p class=MsoNormal><span style='mso-fareast-language:EN-US'>Best regards, </span><span lang=EN-US style='mso-fareast-language:EN-US'><o:p></o:p></span></p><p class=MsoNormal><span style='mso-fareast-language:EN-US'> </span><span lang=EN-US style='mso-fareast-language:EN-US'><o:p></o:p></span></p><p class=MsoNormal><span style='font-size:9.0pt;font-family:"Arial",sans-serif;mso-fareast-language:EN-GB'>Duarte Molha</span><span style='mso-fareast-language:EN-US'> <span lang=EN-US><o:p></o:p></span></span></p><p class=MsoNormal><o:p> </o:p></p></div></body></html>