<div>Hi Daniel,</div>
<div><br></div>
<div>Ah ok great thanks! Thing is though: now none of the 10M variants in ExAC overlap RegulatoryFeatures. Is that expected? I would have expected at least a few...</div>
<div class="mailbox_signature">
<br>-Konrad</div>
<br><br><div class="gmail_quote"><p>On Thu, May 21, 2015 at 2:17 AM, Daniel Zerbino <span dir="ltr"><<a href="mailto:zerbino@ebi.ac.uk" target="_blank">zerbino@ebi.ac.uk</a>></span> wrote:<br></p><blockquote class="gmail_quote" style="margin:0 0 0 .8ex;border-left:1px #ccc solid;padding-left:1ex;"><div>
<div class="moz-cite-prefix">Hello Konrad,<br><br>
this is because on release 79 we replaced the old regulatory build
with the newer version (which we had released for GRCh38 in v76).<br><br>
There would definitely be some moving around of features as both
builds are very different in the way they are computed.<br><br>
Regards,<br><br>
Daniel<br><br>
On 5/21/15 5:28 AM, Konrad Karczewski wrote:<br></div>
<blockquote cite="mid:20150521042917.1CEAB132A40_55D5F1DB@hx-mx2.ebi.ac.uk" type="cite">
Hi Will, everyone,
<div class=""><br class=""></div>
<div class="">Are RegulatoryFeature annotations expected to have
the same results in VEP v79 (GRCh37) as previous versions (e.g.
v77)? When annotating the ExAC VCF, the older versions included
many ENSR* annotations, but v79's do not (same command including
--everything both times). For instance, the following variant
used to overlap ENSR00000528767 but does not seem to in my most
recent version:</div>
<div class=""><br class=""></div>
<div class="">1 13372 . G C</div>
<div class=""><br class=""></div>
<div class="">Any idea why this might be happening? All other
annotations seem fine.<br class=""><div class=""><br class="webkit-block-placeholder"></div>
<div class="">
<div style="color: rgb(0, 0, 0); letter-spacing: normal;
orphans: auto; text-align: start; text-indent: 0px;
text-transform: none; white-space: normal; widows: auto;
word-spacing: 0px; -webkit-text-stroke-width: 0px;
word-wrap: break-word; -webkit-nbsp-mode: space;
-webkit-line-break: after-white-space;" class="">
<div style="color: rgb(0, 0, 0); font-family: Helvetica;
font-size: 12px; font-style: normal; font-variant: normal;
font-weight: normal; letter-spacing: normal; line-height:
normal; orphans: auto; text-align: start; text-indent:
0px; text-transform: none; white-space: normal; widows:
auto; word-spacing: 0px; -webkit-text-stroke-width: 0px;" class="">Thanks!<br class="Apple-interchange-newline">
-Konrad</div>
</div>
</div>
<br class=""></div>
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