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Dear Duarte,<br>
<br>
The gene set in the GRCh37 database is a freeze from release 75.<br>
The variation and regulation annotation is updated when major data
sets are released.<br>
<br>
The gene set however is not updated given our major evidence sources
are updated to GRCh38.<br>
<br>
<br>
Regards,<br>
Magali<br>
<br>
<div class="moz-cite-prefix">On 01/07/2015 11:03, Duarte Molha
wrote:<br>
</div>
<blockquote
cite="mid:CAGqkoEJnNrrFM0FabN2UDKp9pomGAT=wyHZp=cauB9WXFME0gg@mail.gmail.com"
type="cite">
<div dir="ltr">Dear developers
<div><br>
</div>
<div>It was my understanding that ensembl would be keeping 2
databases running in parallel for both GRCh38 and GRCh37 and
so all genes would be receiving annotation updates and both
databases could be queried with the latest and greatest
ensembl perl api.</div>
<div><br>
</div>
<div>However I am finding inconsistencies in gene annotation
what have left me puzzled.</div>
<div><br>
</div>
<div>Take for example gene DNAAF5</div>
<div><br>
</div>
<div><a moz-do-not-send="true"
href="http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=26013">http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=26013</a><br>
</div>
<div><br>
</div>
<div>If you query ensembl GRCh38 V80, the gene is there properly
annotated</div>
<div><br>
</div>
<div><a moz-do-not-send="true"
href="http://www.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000164818;r=7:726701-786475">http://www.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000164818;r=7:726701-786475</a><br>
</div>
<div><br>
</div>
<div>However, on GRCh37 V80, the gene is still annotated with
the previous HGNC symbol HEATR2</div>
<div><br>
</div>
<div><a moz-do-not-send="true"
href="http://grch37.ensembl.org/Multi/Search/Results?q=HEATR2;site=ensembl;page=1">http://grch37.ensembl.org/Multi/Search/Results?q=HEATR2;site=ensembl;page=1</a><br>
</div>
<div><br>
</div>
<div>the ENSEMBL gene ID is the same in both cases : </div>
<div><br>
</div>
<div>ENSG00000164818</div>
<div><br>
</div>
<div>Is my thinking flawed? What is the reason for the
out-of-date gene annotation for this gene?</div>
<div><br>
</div>
<div>Many thanks</div>
<div><br>
</div>
<div>Duarte</div>
<div>
</div>
</div>
<br>
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<br>
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</blockquote>
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