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Hi Treesa,<br>
<br>
We switched to using GRCh38 in release 76, so release 75 was the
last time GRCh37 gene annotation was updated. We are maintaining a
GRCh37 site and database and these have been updated with variant
and regulatory data which you would have access to in a new VEP run,
but there is no change to the transcripts.<br>
<br>
If you are only interested in consequences for public variants, you
could look at the file:<br>
<br>
<a class="moz-txt-link-freetext" href="ftp://ftp.ensembl.org/pub/grch37/update/variation/vcf/homo_sapiens/Homo_sapiens_incl_consequences.vcf.gz">ftp://ftp.ensembl.org/pub/grch37/update/variation/vcf/homo_sapiens/Homo_sapiens_incl_consequences.vcf.gz</a><br>
<br>
You don't say how you ran VEP previously but there is information
you may find useful on how to make it run faster here:<br>
<br>
<a class="moz-txt-link-freetext" href="http://www.ensembl.org/info/docs/tools/vep/script/vep_other.html">http://www.ensembl.org/info/docs/tools/vep/script/vep_other.html</a><br>
<br>
Best wishes,<br>
<br>
Sarah<br>
<br>
<div class="moz-cite-prefix">On 03/12/2015 06:15, binit treesa
wrote:<br>
</div>
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cite="mid:20151203061707.2007022D4EC_65FDE63B@hx-mx1.ebi.ac.uk"
type="cite">
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<div>Hi Ensembl Team,<br>
<br>
Currently we are using homo_sapiens_core_82_37 database.
Previously we created VEP output for homo_sapiens_core_75_37
version. It took lot of time for us to run VEP with all
varaints.<br>
<br>
We think that homo_sapiens_core_82_37 core database contains
more records and there will be count difference (increase)
in number of genes and transcripts. Some genes in version 75
will be retired and 82 version do not have that well.<br>
<br>
Can we use VEP output generated for homo_sapiens_core_75_37
database, for homo_sapiens_core_82_37 data if the Ensembl
gene id, transcript id ,co-ordinates and alleles are
matching in VEP output file?<br>
<br>
Also Whether it is possible to get VEP information from any
sources for Ensembl core 82_37 without running VEP perl
script?<br>
<br>
</div>
Thanks in advance,<br>
</div>
Treesa Binit<br>
</div>
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