<html><head><meta http-equiv="Content-Type" content="text/html charset=utf-8"></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space;" class="">Hi Brad,<div class=""><br class=""></div><div class="">I couldn’t reproduce the problem. Do you get an error message which you can share? Which cache directory is specified in your output file? There should be a line starting with '## Using cache in’. Have you updated your cache files to most recent files from release/90? Could you please try and use —dir_cache (from cache options <a href="http://www.ensembl.org/info/docs/tools/vep/script/vep_options.html" class="">http://www.ensembl.org/info/docs/tools/vep/script/vep_options.html</a>) and see if that works?</div><div class=""><br class=""></div><div class="">Anja</div><div class=""><br class=""><div><blockquote type="cite" class=""><div class="">On 25 Aug 2017, at 17:28, Crone, Bradley <<a href="mailto:bradley-crone@uiowa.edu" class="">bradley-crone@uiowa.edu</a>> wrote:</div><br class="Apple-interchange-newline"><div class=""><div id="divtagdefaultwrapper" dir="ltr" style="font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-stroke-width: 0px; font-size: 12pt; font-family: Calibri, Helvetica, sans-serif;" class=""><div style="margin-top: 0px; margin-bottom: 0px;" class="">Hello,</div><div style="margin-top: 0px; margin-bottom: 0px;" class=""><br class=""></div><div style="margin-top: 0px; margin-bottom: 0px;" class="">I'm having issues with VEP 90 specifying my cache directory with the --dir option.</div><div style="margin-top: 0px; margin-bottom: 0px;" class="">The script ignores my path and defaults to $HOME/.vep. This was not an issue in previous VEP iterations.</div><div style="margin-top: 0px; margin-bottom: 0px;" class=""><br class=""></div><div style="margin-top: 0px; margin-bottom: 0px;" class="">Thanks,</div><div style="margin-top: 0px; margin-bottom: 0px;" class="">Brad Crone<br class=""></div><div style="margin-top: 0px; margin-bottom: 0px;" class=""><br class=""></div><div id="Signature" class=""><div id="divtagdefaultwrapper" style="font-size: 12pt; background-color: rgb(255, 255, 255); font-family: Calibri, Arial, Helvetica, sans-serif, EmojiFont, 'Apple Color Emoji', 'Segoe UI Emoji', NotoColorEmoji, 'Segoe UI Symbol', 'Android Emoji', EmojiSymbols;" class=""><div style="margin-top: 0px; margin-bottom: 0px;" class=""><span id="ms-rterangepaste-start" class=""></span><br class="Apple-interchange-newline"></div><hr style="color: rgb(33, 33, 33); font-size: 15px;" class=""><span style="color: rgb(33, 33, 33); font-size: 15px;" class="">Notice: This UI Health Care e-mail (including attachments) is covered by the Electronic Communications Privacy Act, 18 U.S.C. 2510-2521 and is intended only for the use of the individual or entity to which it is addressed, and may contain information that is privileged, confidential, and exempt from disclosure under applicable law. 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