<html><head><style>body{font-family:Helvetica,Arial;font-size:13px}</style></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space;"><div id="bloop_customfont" style="font-family:Helvetica,Arial;font-size:13px; color: rgba(0,0,0,1.0); margin: 0px; line-height: auto;">Dear VEP users,</div><div id="bloop_customfont" style="font-family:Helvetica,Arial;font-size:13px; color: rgba(0,0,0,1.0); margin: 0px; line-height: auto;"><br></div><div id="bloop_customfont" style="font-family:Helvetica,Arial;font-size:13px; color: rgba(0,0,0,1.0); margin: 0px; line-height: auto;">An issue was found with the following VEP cache files made available for release 91 on 11th December 2017 at ftp://ftp.ensembl.org/pub/release-91/variation/VEP/:</div><div id="bloop_customfont" style="font-family:Helvetica,Arial;font-size:13px; color: rgba(0,0,0,1.0); margin: 0px; line-height: auto;"><br></div><div id="bloop_customfont" style="font-family:Helvetica,Arial;font-size:13px; color: rgba(0,0,0,1.0); margin: 0px; line-height: auto;"><div id="bloop_customfont" style="margin: 0px;">homo_sapiens_merged_vep_91_GRCh37.tar.gz</div><div id="bloop_customfont" style="margin: 0px;">homo_sapiens_merged_vep_91_GRCh38.tar.gz</div><div id="bloop_customfont" style="margin: 0px;">homo_sapiens_refseq_vep_91_GRCh37.tar.gz</div><div id="bloop_customfont" style="margin: 0px;">homo_sapiens_refseq_vep_91_GRCh38.tar.gz</div><div id="bloop_customfont" style="margin: 0px;">homo_sapiens_vep_91_GRCh37.tar.gz</div><div id="bloop_customfont" style="margin: 0px;">homo_sapiens_vep_91_GRCh38.tar.gz</div><div id="bloop_customfont" style="margin: 0px;"><br></div><div id="bloop_customfont" style="margin: 0px;">This issue would manifest as either:</div><div id="bloop_customfont" style="margin: 0px;"> - missing or incorrect allele frequency data from 1000 Genomes, ESP or gnomAD (using —af_1kg, —af_esp, —af_gnomad or —everything)</div><div id="bloop_customfont" style="margin: 0px;"> - repeated warnings/errors like the following:</div><div id="bloop_customfont" style="margin: 0px;"><br></div><div id="bloop_customfont" style="margin: 0px;"><div id="bloop_customfont" style="margin: 0px;">Argument "" isn't numeric in subroutine entry at /homes/user/src/ensembl-vep/modules/Bio/EnsEMBL/VEP/AnnotationSource.pm line 258, <$__ANONIO__> line 134935.</div><div id="bloop_customfont" style="margin: 0px;">Argument "A/G" isn't numeric in subroutine entry at /homes/user/src/ensembl-vep/modules/Bio/EnsEMBL/VEP/AnnotationSource.pm line 258, <$__ANONIO__> line 134935.</div><div id="bloop_customfont" style="margin: 0px;"><br></div><div id="bloop_customfont" style="margin: 0px;">These cache files have now been replaced with corrected versions. If you downloaded any of the above files between 11th and 18th December inclusive, please replace them by re-running the INSTALL.pl script.</div><div id="bloop_customfont" style="margin: 0px;"><br></div><div id="bloop_customfont" style="margin: 0px;">Regards</div><div id="bloop_customfont" style="margin: 0px;"><br></div><div id="bloop_customfont" style="margin: 0px;">Will McLaren</div><div id="bloop_customfont" style="margin: 0px;">Ensembl Variation</div></div></div><div id="bloop_sign_1513696174473767168" class="bloop_sign"></div></body></html>