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<p>Dear Fazulur,</p>
<p>Regarding your VEP command it looks like you missed to add "--"
before the "custom" option:</p>
<p><b>vep -i [vepdir]/examples/homo_sapiens_GRCh37.vcf -cache
--ASSEMBLY GRCh37 --fork 4 --custom
gnomad.exomes.r2.0.1.sites.vcf.gz,gnomADg,vcf,exact,0,AF_AFR,AF_AMR,AF_ASJ,AF_EAS,AF_FIN,AF_NFE,AF_OTH</b></p>
<p>Best regards,<br>
</p>
<pre class="moz-signature" cols="72">Laurent
Ensembl Variation
</pre>
<div class="moz-cite-prefix">On 27/02/2018 19:04, Rehaman wrote:<br>
</div>
<blockquote type="cite"
cite="mid:CAOnJw470Xu2H-w1zoVn4PTWa6fxsS9121kuzrNsJJWoPcSA_vQ@mail.gmail.com">
<div dir="ltr">Dear Ensembl team,
<div><br>
</div>
<div>I am running VEP for GRCh37 assembly and as you mentioned
some of alleles may not get Allele frequencies and so I want
to test custom annotation optio</div>
<div><br>
</div>
<div>I tried running vep with example vcf and getting
"Segmentation Fault" error. </div>
<div><br>
</div>
<div>Command:</div>
<div><br>
</div>
<div><b>vep -i [vepdir]/examples/homo_sapiens_GRCh37.vcf -cache
--ASSEMBLY GRCh37 --fork 4 custom
gnomad.exomes.r2.0.1.sites.vcf.gz,gnomADg,vcf,exact,0,AF_AFR,AF_AMR,AF_ASJ,AF_EAS,AF_FIN,AF_NFE,AF_OTH</b><br>
</div>
<div><br>
</div>
<div>Could you please give me suggestions on this.</div>
<div><br>
</div>
<div>Thanks & Regards</div>
<div>Fazulur Rehaman</div>
</div>
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</pre>
</blockquote>
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