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<p>Hello,</p>
<p>I am a PhD student in bioinformatics within the CRTI in Nantes,
France.<br>
</p>
<p>I am developing Ferret (<a class="moz-txt-link-freetext"
href="http://limousophie35.github.io/Ferret/">http://limousophie35.github.io/Ferret/</a>),
a Java application designed to retrieve annotations from the
VEP REST API using variants id (rsid). This application submits
a https request and extract the sift/polyphen scores and
predictions from the JSON output.<br>
</p>
<p>However, VEP server usually shut down my requests after some
iterations. Please see below some examples of errors returned by
the app: <br>
</p>
<p><i>Server returned HTTP response code: 429 for URL:
<a class="moz-txt-link-freetext"
href="https://rest.ensembl.org/vep/human/id/rs41282276?content-type=application/json">https://rest.ensembl.org/vep/human/id/rs41282276?content-type=application/json</a></i></p>
<p><i>Server returned HTTP response code: 503 for URL:
<a class="moz-txt-link-freetext"
href="https://rest.ensembl.org/vep/human/id/rs543148494?content-type=application/json">https://rest.ensembl.org/vep/human/id/rs543148494?content-type=application/json</a></i></p>
<p>In practice, I use threads to speed up my runtime. Then, the
application submits many requests in a short amount of time.</p>
<p>I wanted to know if there is any way to solve this issue?</p>
<p>Thank you very much for your help.<br>
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<p>Best regards,<br>
</p>
<p>Rokhaya BA</p>
<p>PhD Student in Bioinformatics</p>
<p><br>
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