<html><head><meta http-equiv="Content-Type" content="text/html; charset=us-ascii"></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class="">Hi Ramiro,<div class=""><br class=""></div><div class="">this is not a bug as such because we did not intend to keep the order of the input variants which we loose in our internal LD calculations. But I absolutely agree that this is causing confusions and we will update the endpoint to retain the order of the input variants in the output. This will be updated for our 98 release planned to be out in September.</div><div class=""><br class=""></div><div class="">Best wishes,</div><div class="">Anja</div><div class=""><br class=""></div><div class=""><div><br class=""><blockquote type="cite" class=""><div class="">On 17 Jul 2019, at 17:41, Ramiro Magno <<a href="mailto:ramiro.magno@gmail.com" class="">ramiro.magno@gmail.com</a>> wrote:</div><br class="Apple-interchange-newline"><div class=""><div dir="ltr" class="">Hi<div class=""><br class=""></div><div class="">It seems that the response returned by this endpoint:</div><div class=""><br class=""></div><div class=""><a href="http://rest.ensembl.org/documentation/info/ld_pairwise_get" class="">http://rest.ensembl.org/documentation/info/ld_pairwise_get</a></div><div class=""><br class=""></div><div class="">does not always respect what is variant id1 and variant id2.</div><div class=""><br class=""></div><div class="">Example:</div><div class=""><br class=""></div><div class=""><a href="https://rest.ensembl.org/ld/human/pairwise/rs1042779/rs62255400?population_name=1000GENOMES:phase_3:CEU;d_prime=0;r2=0" class="">https://rest.ensembl.org/ld/human/pairwise/rs1042779/rs62255400?population_name=1000GENOMES:phase_3:CEU;d_prime=0;r2=0</a><br class=""></div><div class=""><br class=""></div><div class="">As per the documentation, I was expecting variant1 = rs1042779, and variant2 = rs62255400 but the actual response is:</div><div class=""><br class=""></div><div class=""> d_prime: '0.999977'<br class=""> population_name: 1000GENOMES:phase_3:CEU<br class=""> r2: '0.271200'<br class=""> variation1: rs62255400<br class=""> variation2: rs1042779<br class=""></div><div class=""><br class=""></div><div class="">The two variants are swapped.</div><div class=""><br class=""></div><div class="">Can you confirm this is a bug?</div><div class=""><br class=""></div><div class="">Cheers, Ramiro</div><div class=""><br class=""></div></div>
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