<html><head><meta http-equiv="Content-Type" content="text/html; charset=utf-8"></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class="">Hi Sigurjon,<div class=""><br class=""></div><div class=""><div class="">VEP only reports overlaps with 'experimentally verified’ motif features. Which means those motif features fully overlap with a relevant ChIP-Seq peak. On the website we are still showing overlaps with unverified motif features. This will be updated for next release 100 when we are only going to show overlaps with 'experimentally verified’ motif features. Our blog <a href="http://www.ensembl.info/2018/10/15/new-ensembl-motif-features/" class="">post</a> gives more details on how we report motif features.</div><div class=""><br class=""></div><div class="">Best wishes,</div><div class="">Anja</div><div class=""><br class=""></div><div><blockquote type="cite" class=""><div class="">On 12 Mar 2020, at 12:53, Sigurjón Axel Guðjónsson <<a href="mailto:Sigurjon.Gudjonsson@decode.is" class="">Sigurjon.Gudjonsson@decode.is</a>> wrote:</div><br class="Apple-interchange-newline"><div class=""><div class="WordSection1" style="page: WordSection1; caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none;"><div style="margin: 0cm 0cm 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><o:p class=""> </o:p></div><pre style="margin: 0cm 0cm 0.0001pt; font-size: 10pt; font-family: "Courier New";" class="">Hi,<o:p class=""></o:p></pre><pre style="margin: 0cm 0cm 0.0001pt; font-size: 10pt; font-family: "Courier New";" class=""><o:p class=""> </o:p></pre><pre style="margin: 0cm 0cm 0.0001pt; font-size: 10pt; font-family: "Courier New";" class="">I am using VEP r99 to annotate i.e. rs759323910, and I notice that VEP only annotates MotifFeature ENSM00524563717 (ENSPFM0379). <o:p class=""></o:p></pre><pre style="margin: 0cm 0cm 0.0001pt; font-size: 10pt; font-family: "Courier New";" class="">The web browser does hower annotate 2 MotifFeatures ENSM00524563717 (ENSPFM0588) and ENSM00489900360 (ENSPFM0379). <o:p class=""></o:p></pre><pre style="margin: 0cm 0cm 0.0001pt; font-size: 10pt; font-family: "Courier New";" class=""><o:p class=""> </o:p></pre><pre style="margin: 0cm 0cm 0.0001pt; font-size: 10pt; font-family: "Courier New";" class="">See:<o:p class=""></o:p></pre><pre style="margin: 0cm 0cm 0.0001pt; font-size: 10pt; font-family: "Courier New";" class=""><a href="http://www.ensembl.org/Homo_sapiens/Variation/Mappings?db=core;v=rs759323910;vdb=variation" style="color: rgb(149, 79, 114); text-decoration: underline;" class="">http://www.ensembl.org/Homo_sapiens/Variation/Mappings?db=core;v=rs759323910;vdb=variation</a><o:p class=""></o:p></pre><pre style="margin: 0cm 0cm 0.0001pt; font-size: 10pt; font-family: "Courier New";" class=""><o:p class=""> </o:p></pre><pre style="margin: 0cm 0cm 0.0001pt; font-size: 10pt; font-family: "Courier New";" class="">Is there any valid reason for this discrepancy or is this a bug in VEP r99?<o:p class=""></o:p></pre><pre style="margin: 0cm 0cm 0.0001pt; font-size: 10pt; font-family: "Courier New";" class=""><o:p class=""> </o:p></pre><pre style="margin: 0cm 0cm 0.0001pt; font-size: 10pt; font-family: "Courier New";" class="">Best regards,<o:p class=""></o:p></pre><pre style="margin: 0cm 0cm 0.0001pt; font-size: 10pt; font-family: "Courier New";" class=""><o:p class=""> </o:p></pre><pre style="margin: 0cm 0cm 0.0001pt; font-size: 10pt; font-family: "Courier New";" class="">Sigurjon A. Gudjonsson<o:p class=""></o:p></pre><pre style="margin: 0cm 0cm 0.0001pt; font-size: 10pt; font-family: "Courier New";" class="">Bioinformatics Group<o:p class=""></o:p></pre><pre style="margin: 0cm 0cm 0.0001pt; font-size: 10pt; font-family: "Courier New";" class="">Decode Genetics<o:p class=""></o:p></pre></div><span style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none; float: none; display: inline !important;" class="">_______________________________________________</span><br style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none;" class=""><span style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none; float: none; display: inline !important;" class="">Dev mailing list </span><a href="mailto:Dev@ensembl.org" style="color: rgb(149, 79, 114); text-decoration: underline; font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px;" class="">Dev@ensembl.org</a><br style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none;" class=""><span style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none; float: none; display: inline !important;" class="">Posting guidelines and subscribe/unsubscribe info:<span class="Apple-converted-space"> </span></span><a href="https://lists.ensembl.org/mailman/listinfo/dev_ensembl.org" style="color: rgb(149, 79, 114); text-decoration: underline; font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px;" class="">https://lists.ensembl.org/mailman/listinfo/dev_ensembl.org</a><br style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none;" class=""><span style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none; float: none; display: inline !important;" class="">Ensembl Blog:<span class="Apple-converted-space"> </span></span><a href="http://www.ensembl.info/" style="color: rgb(149, 79, 114); text-decoration: underline; font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px;" class="">http://www.ensembl.info/</a></div></blockquote></div><br class=""></div></body></html>