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<p class="MsoNormal" style="margin-bottom:12.0pt"><b><span style="font-size:12.0pt;color:black">From:
</span></b><span style="font-size:12.0pt;color:black">Siyang Feng <feng.siy@northeastern.edu><br>
<b>Date: </b>Monday, June 17, 2024 at 10:21</span><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:black"> </span><span style="font-size:12.0pt;color:black">AM<br>
<b>To: </b>dev@ensembl.org <dev@ensembl.org><br>
<b>Subject: </b>Inquiry Regarding Backend Code for Ensembl VEP Tool<o:p></o:p></span></p>
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<p><span style="font-size:10.0pt;font-family:Helvetica;color:black">Dear Ensembl Team,</span><o:p></o:p></p>
<p style="font-variant-caps:normal;orphans:auto;text-align:start;widows:auto;word-spacing:0px">
<span style="font-size:10.0pt;font-family:Helvetica;color:black">I hope this message finds you well. I’m Siyang Feng, a student major in Computer Science.</span><o:p></o:p></p>
<p style="font-variant-caps:normal;orphans:auto;text-align:start;widows:auto;word-spacing:0px">
<span style="font-size:10.0pt;font-family:Helvetica;color:black">I am writing to inquire about the backend implementation of the Variant Effect Predictor (VEP) tool available on your website, specifically at the following URL: <a href="https://useast.ensembl.org/Homo_sapiens/Tools/VEP" target="_new">https://useast.ensembl.org/Homo_sapiens/Tools/VEP</a>.</span><o:p></o:p></p>
<p style="font-variant-caps:normal;orphans:auto;text-align:start;widows:auto;word-spacing:0px">
<span style="font-size:10.0pt;font-family:Helvetica;color:black">I’m interested in understanding the technical details and architecture of the backend system that powers the VEP tool on your website. We are particularly keen on the following aspects:</span><o:p></o:p></p>
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<li class="MsoNormal" style="color:black;mso-list:l0 level1 lfo1"><span style="font-family:Helvetica">The backend codebase or repository, if available.</span><span style="font-size:12.0pt"><o:p></o:p></span></li><li class="MsoNormal" style="color:black;mso-list:l0 level1 lfo1"><span style="font-family:Helvetica">The process for handling and processing the user-submitted variant data.</span><span style="font-size:12.0pt"><o:p></o:p></span></li><li class="MsoNormal" style="color:black;mso-list:l0 level1 lfo1"><span style="font-family:Helvetica">The parameters used in the VEP tool and how they are managed and utilized.</span><span style="font-size:12.0pt"><o:p></o:p></span></li><li class="MsoNormal" style="color:black;mso-list:l0 level1 lfo1"><span style="font-family:Helvetica">Any documentation or resources that could help us integrate a similar solution in our own backend system.</span><span style="font-size:12.0pt"><o:p></o:p></span></li></ol>
<p style="font-variant-caps:normal;orphans:auto;text-align:start;widows:auto;word-spacing:0px">
<span style="font-size:10.0pt;font-family:Helvetica;color:black">I greatly appreciate the efforts of the Ensembl team in providing such a valuable resource to the scientific community. Thank you for your time and assistance.</span><o:p></o:p></p>
<p style="font-variant-caps:normal;orphans:auto;text-align:start;widows:auto;word-spacing:0px">
<span style="font-size:10.0pt;font-family:Helvetica;color:black">Siyang Feng</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt"> </span><span style="font-size:12.0pt"><o:p></o:p></span></p>
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