<html><head><meta http-equiv="content-type" content="text/html; charset=us-ascii"></head><body style="overflow-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;"><div dir="auto" style="overflow-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;"><div dir="auto" style="overflow-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;"><div dir="auto" style="overflow-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;"><div style="white-space: pre-wrap; margin: 0px; padding: 0px; caret-color: rgb(41, 42, 46); color: rgb(41, 42, 46);">Dear Developers,</div><div style="white-space: pre-wrap; margin: 0.75rem 0px 0px; padding: 0px; caret-color: rgb(41, 42, 46); color: rgb(41, 42, 46);">As highlighted in our <a title="https://academic.oup.com/nar/article/53/D1/D948/7916352" data-renderer-mark="true" href="https://academic.oup.com/nar/article/53/D1/D948/7916352" data-is-router-link="false" class="_mizu1p6i _1ah31bk5 _ra3xnqa1 _128m1bk5 _1cvmnqa1 _4davt94y _4bfu18uv _1hms8stv _ajmmnqa1 _vchhusvi _kqswh2mm _syaz14q2 _ect41gqc _1a3b18uv _4fpr8stv _5goinqa1 _f8pj14q2 _9oik18uv _1bnxglyw _jf4cnqa1 _30l314q2 _1nrm18uv _c2waglyw _1iohnqa1 _9h8h16c2 _1053w7te _1ienw7te _n0fxw7te _1vhvg3x0" data-testid="link-with-safety" style="color: rgb(94, 77, 178); position: relative; box-sizing: border-box; text-decoration-color: initial; text-decoration-style: solid;">publication in Nucleic Acids Research</a>, work on the new Ensembl platform is well underway and can already be explored at <a title="http://beta.ensembl.org" data-renderer-mark="true" href="http://beta.ensembl.org/" data-is-router-link="false" class="_mizu1p6i _1ah31bk5 _ra3xnqa1 _128m1bk5 _1cvmnqa1 _4davt94y _4bfu18uv _1hms8stv _ajmmnqa1 _vchhusvi _kqswh2mm _syaz14q2 _ect41gqc _1a3b18uv _4fpr8stv _5goinqa1 _f8pj14q2 _9oik18uv _1bnxglyw _jf4cnqa1 _30l314q2 _1nrm18uv _c2waglyw _1iohnqa1 _9h8h16c2 _1053w7te _1ienw7te _n0fxw7te _1vhvg3x0" data-testid="link-with-safety" style="color: rgb(94, 77, 178); position: relative; box-sizing: border-box; text-decoration-color: initial; text-decoration-style: solid;">beta.ensembl.org</a>. As we continue to transition to the new platform, we would like to share important updates on upcoming changes that will affect how Ensembl data can be accessed programmatically.</div><div style="white-space: pre-wrap; margin: 0.75rem 0px 0px; padding: 0px; caret-color: rgb(41, 42, 46); color: rgb(41, 42, 46);">With the release of Ensembl 116 (vertebrates) and Ensembl Genomes 63 (non-vertebrates), which we expect in spring 2026, the current Ensembl APIs and public MySQL servers will be frozen. The FTP access points <a title="https://ftp.ensembl.org/pub/" data-renderer-mark="true" href="https://ftp.ensembl.org/pub/" data-is-router-link="false" class="_mizu1p6i _1ah31bk5 _ra3xnqa1 _128m1bk5 _1cvmnqa1 _4davt94y _4bfu18uv _1hms8stv _ajmmnqa1 _vchhusvi _kqswh2mm _syaz14q2 _ect41gqc _1a3b18uv _4fpr8stv _5goinqa1 _f8pj14q2 _9oik18uv _1bnxglyw _jf4cnqa1 _30l314q2 _1nrm18uv _c2waglyw _1iohnqa1 _9h8h16c2 _1053w7te _1ienw7te _n0fxw7te _1vhvg3x0" data-testid="link-with-safety" style="color: rgb(94, 77, 178); position: relative; box-sizing: border-box; text-decoration-color: initial; text-decoration-style: solid;">https://ftp.ensembl.org/</a> and <a title="https://ftp.ensemblgenomes.ebi.ac.uk/pub/" data-renderer-mark="true" href="https://ftp.ensemblgenomes.ebi.ac.uk/pub/" data-is-router-link="false" class="_mizu1p6i _1ah31bk5 _ra3xnqa1 _128m1bk5 _1cvmnqa1 _4davt94y _4bfu18uv _1hms8stv _ajmmnqa1 _vchhusvi _kqswh2mm _syaz14q2 _ect41gqc _1a3b18uv _4fpr8stv _5goinqa1 _f8pj14q2 _9oik18uv _1bnxglyw _jf4cnqa1 _30l314q2 _1nrm18uv _c2waglyw _1iohnqa1 _9h8h16c2 _1053w7te _1ienw7te _n0fxw7te _1vhvg3x0" data-testid="link-with-safety" style="color: rgb(94, 77, 178); position: relative; box-sizing: border-box; text-decoration-color: initial; text-decoration-style: solid;">https://ftp.ensemblgenomes.ebi.ac.uk/</a> will also be frozen. Access to the existing endpoints and databases will remain until new Ensembl platforms offer equivalent functionality. However, they will no longer receive new data or be updated.</div><div style="white-space: pre-wrap; margin: 0.75rem 0px 0px; padding: 0px; caret-color: rgb(41, 42, 46); color: rgb(41, 42, 46);">Going forward, all new and updated data will be made available exclusively through the new Ensembl site, <a title="http://beta.ensembl.org" data-renderer-mark="true" href="http://beta.ensembl.org/" data-is-router-link="false" class="_mizu1p6i _1ah31bk5 _ra3xnqa1 _128m1bk5 _1cvmnqa1 _4davt94y _4bfu18uv _1hms8stv _ajmmnqa1 _vchhusvi _kqswh2mm _syaz14q2 _ect41gqc _1a3b18uv _4fpr8stv _5goinqa1 _f8pj14q2 _9oik18uv _1bnxglyw _jf4cnqa1 _30l314q2 _1nrm18uv _c2waglyw _1iohnqa1 _9h8h16c2 _1053w7te _1ienw7te _n0fxw7te _1vhvg3x0" data-testid="link-with-safety" style="color: rgb(94, 77, 178); position: relative; box-sizing: border-box; text-decoration-color: initial; text-decoration-style: solid;">beta.ensembl.org</a>. We are actively developing programmatic access to new data, such as the <a title="https://beta.ensembl.org/help/articles/using-graph-ql" data-renderer-mark="true" href="https://beta.ensembl.org/help/articles/using-graph-ql" data-is-router-link="false" class="_mizu1p6i _1ah31bk5 _ra3xnqa1 _128m1bk5 _1cvmnqa1 _4davt94y _4bfu18uv _1hms8stv _ajmmnqa1 _vchhusvi _kqswh2mm _syaz14q2 _ect41gqc _1a3b18uv _4fpr8stv _5goinqa1 _f8pj14q2 _9oik18uv _1bnxglyw _jf4cnqa1 _30l314q2 _1nrm18uv _c2waglyw _1iohnqa1 _9h8h16c2 _1053w7te _1ienw7te _n0fxw7te _1vhvg3x0" data-testid="link-with-safety" style="color: rgb(94, 77, 178); position: relative; box-sizing: border-box; text-decoration-color: initial; text-decoration-style: solid;">Ensembl GraphQL service</a>, the <a title="https://beta.ensembl.org/help/articles/accessing-ensembl-s-refget-services" data-renderer-mark="true" href="https://beta.ensembl.org/help/articles/accessing-ensembl-s-refget-services" data-is-router-link="false" class="_mizu1p6i _1ah31bk5 _ra3xnqa1 _128m1bk5 _1cvmnqa1 _4davt94y _4bfu18uv _1hms8stv _ajmmnqa1 _vchhusvi _kqswh2mm _syaz14q2 _ect41gqc _1a3b18uv _4fpr8stv _5goinqa1 _f8pj14q2 _9oik18uv _1bnxglyw _jf4cnqa1 _30l314q2 _1nrm18uv _c2waglyw _1iohnqa1 _9h8h16c2 _1053w7te _1ienw7te _n0fxw7te _1vhvg3x0" data-testid="link-with-safety" style="color: rgb(94, 77, 178); position: relative; box-sizing: border-box; text-decoration-color: initial; text-decoration-style: solid;">Ensembl refget service</a>, and the <a title="https://ftp.ebi.ac.uk/pub/ensemblorganisms/" data-renderer-mark="true" href="https://ftp.ebi.ac.uk/pub/ensemblorganisms/" data-is-router-link="false" class="_mizu1p6i _1ah31bk5 _ra3xnqa1 _128m1bk5 _1cvmnqa1 _4davt94y _4bfu18uv _1hms8stv _ajmmnqa1 _vchhusvi _kqswh2mm _syaz14q2 _ect41gqc _1a3b18uv _4fpr8stv _5goinqa1 _f8pj14q2 _9oik18uv _1bnxglyw _jf4cnqa1 _30l314q2 _1nrm18uv _c2waglyw _1iohnqa1 _9h8h16c2 _1053w7te _1ienw7te _n0fxw7te _1vhvg3x0" data-testid="link-with-safety" style="color: rgb(94, 77, 178); position: relative; box-sizing: border-box; text-decoration-color: initial; text-decoration-style: solid;">Ensembl Beta FTP</a>. Please note that the structure of the <a title="https://ftp.ebi.ac.uk/pub/ensemblorganisms/" data-renderer-mark="true" href="https://ftp.ebi.ac.uk/pub/ensemblorganisms/" data-is-router-link="false" class="_mizu1p6i _1ah31bk5 _ra3xnqa1 _128m1bk5 _1cvmnqa1 _4davt94y _4bfu18uv _1hms8stv _ajmmnqa1 _vchhusvi _kqswh2mm _syaz14q2 _ect41gqc _1a3b18uv _4fpr8stv _5goinqa1 _f8pj14q2 _9oik18uv _1bnxglyw _jf4cnqa1 _30l314q2 _1nrm18uv _c2waglyw _1iohnqa1 _9h8h16c2 _1053w7te _1ienw7te _n0fxw7te _1vhvg3x0" data-testid="link-with-safety" style="color: rgb(94, 77, 178); position: relative; box-sizing: border-box; text-decoration-color: initial; text-decoration-style: solid;">Ensembl Beta FTP</a> is under active development and is expected to change. We will inform you via this <a title="https://lists.ensembl.org/mailman/listinfo/dev_ensembl.org" data-renderer-mark="true" href="https://lists.ensembl.org/mailman/listinfo/dev_ensembl.org" data-is-router-link="false" class="_mizu1p6i _1ah31bk5 _ra3xnqa1 _128m1bk5 _1cvmnqa1 _4davt94y _4bfu18uv _1hms8stv _ajmmnqa1 _vchhusvi _kqswh2mm _syaz14q2 _ect41gqc _1a3b18uv _4fpr8stv _5goinqa1 _f8pj14q2 _9oik18uv _1bnxglyw _jf4cnqa1 _30l314q2 _1nrm18uv _c2waglyw _1iohnqa1 _9h8h16c2 _1053w7te _1ienw7te _n0fxw7te _1vhvg3x0" data-testid="link-with-safety" style="color: rgb(94, 77, 178); position: relative; box-sizing: border-box; text-decoration-color: initial; text-decoration-style: solid;">Ensembl Dev mailing list</a> as soon as new resources or updates become available.</div><div style="white-space: pre-wrap; margin: 0.75rem 0px 0px; padding: 0px; caret-color: rgb(41, 42, 46); color: rgb(41, 42, 46);">Please also note that in summer 2026, the URL for <a title="http://ensembl.org" data-renderer-mark="true" href="http://ensembl.org/" data-is-router-link="false" class="_mizu1p6i _1ah31bk5 _ra3xnqa1 _128m1bk5 _1cvmnqa1 _4davt94y _4bfu18uv _1hms8stv _ajmmnqa1 _vchhusvi _kqswh2mm _syaz14q2 _ect41gqc _1a3b18uv _4fpr8stv _5goinqa1 _f8pj14q2 _9oik18uv _1bnxglyw _jf4cnqa1 _30l314q2 _1nrm18uv _c2waglyw _1iohnqa1 _9h8h16c2 _1053w7te _1ienw7te _n0fxw7te _1vhvg3x0" data-testid="link-with-safety" style="color: rgb(94, 77, 178); position: relative; box-sizing: border-box; text-decoration-color: initial; text-decoration-style: solid;">ensembl.org</a> will redirect to the site currently hosted at <a title="http://beta.ensembl.org" data-renderer-mark="true" href="http://beta.ensembl.org/" data-is-router-link="false" class="_mizu1p6i _1ah31bk5 _ra3xnqa1 _128m1bk5 _1cvmnqa1 _4davt94y _4bfu18uv _1hms8stv _ajmmnqa1 _vchhusvi _kqswh2mm _syaz14q2 _ect41gqc _1a3b18uv _4fpr8stv _5goinqa1 _f8pj14q2 _9oik18uv _1bnxglyw _jf4cnqa1 _30l314q2 _1nrm18uv _c2waglyw _1iohnqa1 _9h8h16c2 _1053w7te _1ienw7te _n0fxw7te _1vhvg3x0" data-testid="link-with-safety" style="color: rgb(94, 77, 178); position: relative; box-sizing: border-box; text-decoration-color: initial; text-decoration-style: solid;">beta.ensembl.org</a>. We will implement URL resolution to ensure the navigation of hard-coded URL links remains intact as far as possible. The Ensembl 116 and corresponding Ensembl Genomes 63 sites will be moved to our <a title="https://www.ensembl.org/info/website/archives/index.html" data-renderer-mark="true" href="https://www.ensembl.org/info/website/archives/index.html" data-is-router-link="false" class="_mizu1p6i _1ah31bk5 _ra3xnqa1 _128m1bk5 _1cvmnqa1 _4davt94y _4bfu18uv _1hms8stv _ajmmnqa1 _vchhusvi _kqswh2mm _syaz14q2 _ect41gqc _1a3b18uv _4fpr8stv _5goinqa1 _f8pj14q2 _9oik18uv _1bnxglyw _jf4cnqa1 _30l314q2 _1nrm18uv _c2waglyw _1iohnqa1 _9h8h16c2 _1053w7te _1ienw7te _n0fxw7te _1vhvg3x0" data-testid="link-with-safety" style="color: rgb(94, 77, 178); position: relative; box-sizing: border-box; text-decoration-color: initial; text-decoration-style: solid;">archive</a> collection, and these will maintain enhanced tool functionality beyond what standard archives offer, including the Ensembl VEP interface. We will begin to sunset the tool functionality of these sites when sufficient parity is offered through <a title="http://beta.ensembl.org" data-renderer-mark="true" href="http://beta.ensembl.org/" data-is-router-link="false" class="_mizu1p6i _1ah31bk5 _ra3xnqa1 _128m1bk5 _1cvmnqa1 _4davt94y _4bfu18uv _1hms8stv _ajmmnqa1 _vchhusvi _kqswh2mm _syaz14q2 _ect41gqc _1a3b18uv _4fpr8stv _5goinqa1 _f8pj14q2 _9oik18uv _1bnxglyw _jf4cnqa1 _30l314q2 _1nrm18uv _c2waglyw _1iohnqa1 _9h8h16c2 _1053w7te _1ienw7te _n0fxw7te _1vhvg3x0" data-testid="link-with-safety" style="color: rgb(94, 77, 178); position: relative; box-sizing: border-box; text-decoration-color: initial; text-decoration-style: solid;">beta.ensembl.org</a>.</div><div style="white-space: pre-wrap; margin: 0.75rem 0px 0px; padding: 0px; caret-color: rgb(41, 42, 46); color: rgb(41, 42, 46);">We encourage you to review your use of Ensembl APIs and MySQL servers, and plan to migrate your workflows to the new Ensembl platform over time.</div><div style="white-space: pre-wrap; margin: 0.75rem 0px 0px; padding: 0px; caret-color: rgb(41, 42, 46); color: rgb(41, 42, 46);">We greatly appreciate your collaboration and patience during this transition. If you have any questions, concerns or require assistance, please do not hesitate to contact us via the Ensembl Helpdesk at <a title="mailto:helpdesk@ensembl.org" data-renderer-mark="true" href="mailto:helpdesk@ensembl.org" data-is-router-link="false" class="_mizu1p6i _1ah31bk5 _ra3xnqa1 _128m1bk5 _1cvmnqa1 _4davt94y _4bfu18uv _1hms8stv _ajmmnqa1 _vchhusvi _kqswh2mm _syaz14q2 _ect41gqc _1a3b18uv _4fpr8stv _5goinqa1 _f8pj14q2 _9oik18uv _1bnxglyw _jf4cnqa1 _30l314q2 _1nrm18uv _c2waglyw _1iohnqa1 _9h8h16c2 _1053w7te _1ienw7te _n0fxw7te _1vhvg3x0" data-testid="link-with-safety" style="color: rgb(94, 77, 178); position: relative; box-sizing: border-box; text-decoration-color: initial; text-decoration-style: solid;"><u data-renderer-mark="true">helpdesk@ensembl.org</u></a>.</div><div style="white-space: pre-wrap; margin: 0.75rem 0px 0px; padding: 0px; caret-color: rgb(41, 42, 46); color: rgb(41, 42, 46);">All the best,</div><div style="white-space: pre-wrap; margin: 0.75rem 0px 0px; padding: 0px; caret-color: rgb(41, 42, 46); color: rgb(41, 42, 46);">Ensembl Outreach<br>(on behalf of the Ensembl team)</div><div style="white-space: pre-wrap; margin: 0.75rem 0px 0px; padding: 0px; caret-color: rgb(41, 42, 46); color: rgb(41, 42, 46);"><br></div>
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